3.3 Correlation of TAC exposure across different time periods
The trend-lines for TAC C0 and IPV are depicted in
Figure 2, illustrating significant fluctuations in TAC concentration and
consistently high IPV values across all time periods. Furthermore, the
change trends of these parameters at different time points exhibit
similarity. TAC C0 and IPV showed significant
correlation between 3–12 months and 12–24 months
(TAC C0: r =
0.541, P < 0.001; TAC IPV: r = 0.231, P =
0.002), so we used the data during 3–12 months for all further analyses
(n = 224). The distribution of the TAC C0 and IPV
during this time period are shown in Figure S1. In the outcome analysis,
TAC C0 were categorized into two groups: High
C0 (TAC C0 >= 8 ng/mL) and
Low C0 (TAC C0 < 8 ng/mL),
while TAC IPV values were classified as High IPV (TAC IPV
>= 30%) and Low IPV (TAC IPV < 30%)
(Supplementary Figure 1).
3.4 Occurrence and risk
factors for clinical outcomes