Figure 3. Interaction between TAMs secretion and autophagy. M1 macrophages secrete NO, iNOS, IL-6, IL-23, IL-12, TNF-α, IL-1β, CXCL9, CXCL10, ROS; M2 macrophages secrete Arg-1, CCL18, IL-10, IL-1β, IL-17, MRC1; IL-17 secreted by M2 macrophages induces autophagy and inhibits apoptosis; by inhibiting the By inhibiting the autophagy of M2 macrophages, it promotes the secretion of TGF-β1, which promotes the occurrence of EMT in tumor cells; TAM can secrete GDNF to induce autophagy and thus promote the metastasis of tumor cells; TAM can secrete H19 to induce the occurrence of autophagy and promote the growth of tumor cells; inhibiting the autophagy of TAM causes TAM to secrete Gal-1, which promotes the growth and metastasis of tumor cells.