Figure 2. Interaction between TAMs polarization and autophagy. Inhibition of autophagy in M2 macrophages promotes repolarization of M1 macrophages, which promotes sensitivity of tumor cells to chemotherapeutic agents and/or infiltration of anti-tumor immune cells for anti-tumor immune response; HMGB1 secreted by tumor cells induces autophagy in M2 macrophages and promotes polarization of M2 macrophages, which promotes sensitivity of tumor cells to drugs; autophagy in tumor cells H-GDEs induce autophagy in TAM, which promotes M2 macrophage polarization and tumor cell proliferation and migration; induce autophagy in M2 macrophages and promote M1 macrophage repolarization, which inhibits tumor cell growth; promote the release of the autophagosome TRAP by tumor cells; promote the release of the autophagosome TRAP by tumor cells; promote the release of the autophagosome TRAP by tumor cells; and promote the release of the autophagosome TRAP by tumor cells. cells to release the autophagosome TRAP, which induced M2 macrophage polarization and inhibited M1 macrophage repolarization, thereby suppressing anti-tumor immune responses.