References
[1] HYUNA S, JACQUES F, L. S R, et al. Global Cancer Statistics
2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36
Cancers in 185 Countries [J]. CA: A Cancer Journal for Clinicians,
2021, 71(3).
[2] CHANGFA X, XUESI D, HE L, et al. Cancer statistics in China and
United States, 2022: profiles, trends, and determinants [J]. Chinese
Medical Journal, 2022.
[3] AALIA B, YU-QIAN W, XIAO-XIA H, et al. A
miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis
controls testicular germ cell tumor growth [J]. Cell death &
disease, 2018, 9(10).
[4] COSITHA S, J G E, KEN L, et al. Current perspectives on the
tumor microenvironment in hepatocellular carcinoma [J]. Hepatology
international, 2020, (prepublish).
[5] 沈容芳. 结直肠癌上皮组织与微环境细胞相互作用模式研究 [D];
北京协和医学院, 2022.
[6] MARTHA L-Y, LUCA C, W P J. Macrophage targeting in cancer
[J]. Annals of the New York Academy of Sciences, 2020, 1499(1).
[7] ZHE G, SHUZHE D. The Crosstalk Between Tumor-Associated
Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted
Therapy [J]. Frontiers in Oncology, 2020.
[8] YANG Q, GUO N, ZHOU Y, et al. The role of tumor-associated
macrophages (TAMs) in tumor progression and relevant advance in targeted
therapy [J]. Acta Pharmaceutica Sinica B, 2020, 10(11).
[9] MALEKGHASEMI S, MAJIDI J, BAGHBANZADEH A, et al.
Tumor-Associated Macrophages: Protumoral Macrophages in Inflammatory
Tumor Microenvironment [J]. Advanced Pharmaceutical Bulletin, 2020,
10(4).
[10] LI Y, YI Z. Tumor-associated macrophages: from basic research
to clinical application [J]. Journal of hematology & oncology,
2017, 10(1).
[11] NGAMBENJAWONG C, GUSTAFSON H H, PUN S H. Progress in
tumor-associated macrophage (TAM)-targeted therapeutics [J].
Advanced Drug Delivery Reviews, 2017, 114.
[12] CHEN S J, LIAN G D, LI J J, et al. Tumor-driven like
macrophages induced by conditioned media from pancreatic ductal
adenocarcinoma promote tumor metastasis via secreting IL-8 [J].
Cancer Med, 2018, 7(11): 5679-90.
[13] HAO W, XIANGXIANG Z, DALI H, et al. Tumour-associated
macrophages mediate the invasion and metastasis of bladder cancer cells
through CXCL8 [J]. PeerJ, 2020, 8.
[14] QIU S-Q, WAAIJER S, ZWAGER M C, et al. Tumor-associated
macrophages in breast cancer: Innocent bystander or important player?
[J]. Cancer Treatment Reviews, 2018, 70.
[15] R G S, L M R, W D B, et al. PD-1 expression by
tumour-associated macrophages inhibits phagocytosis and tumour immunity
[J]. Nature, 2017, 545(7655).
[16] BRIAN D, SALMA A, F C M, et al. PD-L1 engagement on T cells
promotes self-tolerance and suppression of neighboring macrophages and
effector T cells in cancer [J]. Nature immunology, 2020, 21(4).
[17] NIKOLAOS P, QI W, LAURA S, et al. Revisiting the PD-1 pathway
[J]. Science advances, 2020, 6(38).
[18] MIZUSHIMA N, LEVINE B. Autophagy in Human Diseases [J]. New
England Journal of Medicine, 2020, 383(16).
[19] ECE K, YENER K, SüMER B. Contrast effects of autophagy in the
treatment of bladder cancer [J]. Experimental biology and medicine
(Maywood, NJ), 2020.
[20] ISHIMWE N, ZHANG W, QIAN J, et al. Autophagy regulation as a
promising approach for improving cancer immunotherapy [J]. Cancer
Letters, 2020, 475(C).
[21] XIAOHUA L, SHIKUN H, BINYUN M. Autophagy and autophagy-related
proteins in cancer [J]. Molecular cancer, 2020, 19(1).
[22] WEIYA C, JINHONG L, KEPENG Y, et al. An overview of autophagy:
Mechanism, regulation and research progress [J]. Bulletin du Cancer,
2021, (prepublish).
[23] WANG L, KLIONSKY D, SHEN H. The emerging mechanisms and
functions of microautophagy [J]. Nature reviews Molecular cell
biology, 2023, 24(3): 186-203.
[24] VIRGINIE H, SEBASTIAN W, JACKSON R A, et al. Modulating
Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer
[J]. Cells, 2022, 11(16).
[25] TSUYOSHI K, TAMOTSU Y. Autophagosome biogenesis and human
health [J]. Cell discovery, 2020, 6(1).
[26] SREEDEVI P, RAVI M. Facets of Autophagy Based Unconventional
Protein Secretion–The Road Less Traveled [J]. Frontiers in
Molecular Biosciences, 2020, 7.
[27] JACOB N, MARY T S. Autophagy-dependent secretion: mechanism,
factors secreted, and disease implications [J]. Autophagy, 2019,
15(10).
[28] HUN K Y, SUP K M, BIN L, et al. Secretory autophagy machinery
and vesicular trafficking are involved in HMGB1 secretion [J].
Autophagy, 2020, 17(9).
[29] ODETE B S, NATHALIA L S, ROGER C, et al. Secretory Autophagy
Forges a Therapy Resistant Microenvironment in Melanoma [J].
Cancers, 2022, 14(1).
[30] GUERRIERO J L. Macrophages: The Road Less Traveled, Changing
Anticancer Therapy [J]. Trends in Molecular Medicine, 2018, 24(5).
[31] LV L-L, FENG Y, WU M, et al. Exosomal miRNA-19b-3p of tubular
epithelial cells promotes M1 macrophage activation in kidney injury
[J]. Cell Death & Differentiation: Official journal of the ADMC
Associazione Differenziamento e Morte Cellulare, 2020, 27(3).
[32] WU K, YUAN Y, YU H, et al. The gut microbial metabolite
trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage
polarization in mice [J]. Blood, 2020, 136(4): 501-15.
[33] RUI L, RUI Z, HUI W, et al. Gut microbiota-stimulated cathepsin
K secretion mediates TLR4-dependent M2 macrophage polarization and
promotes tumor metastasis in colorectal cancer [J]. Cell death and
differentiation, 2019, 26(11).
[34] KHOSROW K, JASMINE K, NIHARIKA N. Macrophage Reprogramming and
Cancer Therapeutics: Role of iNOS-Derived NO [J]. Cells, 2021,
10(11).
[35] GAMBARDELLA V, CASTILLO J, TARAZONA N, et al. The role of
tumor-associated macrophages in gastric cancer development and their
potential as a therapeutic target [J]. Cancer Treatment Reviews,
2020, 86(C).
[36] CHEN Y, WEN H, ZHOU C, et al. TNF-α derived from M2
tumor-associated macrophages promotes epithelial-mesenchymal transition
and cancer stemness through the Wnt/β-catenin pathway in SMMC-7721
hepatocellular carcinoma cells [J]. Experimental cell research,
2019, 378(1): 41-50.
[37] YONG L, JOHNIE H, QING L, et al. TFEB is a master regulator of
tumor-associated macrophages in breast cancer [J]. Journal for
immunotherapy of cancer, 2020, 8(1).
[38] ARLAUCKAS S P, GARREN S B, GARRIS C S, et al. Arg1 expression
defines immunosuppressive subsets of tumor-associated macrophages
[J]. Theranostics, 2018, 8(21): 5842-54.
[39] POILLET-PEREZ L, XIE X, ZHAN L, et al. Autophagy maintains
tumour growth through circulating arginine [J]. Nature, 2018,
563(7732): 569-73.
[40] SMITH L K, BOUKHALED G M, CONDOTTA S A, et al. Interleukin-10
Directly Inhibits CD8(+) T Cell Function by Enhancing N-Glycan Branching
to Decrease Antigen Sensitivity [J]. Immunity, 2018, 48(2): 299-312
e5.
[41] COLAK S, TEN DIJKE P. Targeting TGF-beta Signaling in Cancer
[J]. Trends Cancer, 2017, 3(1): 56-71.
[42] WU M-Y, LU J-H. Autophagy and Macrophage Functions:
Inflammatory Response and Phagocytosis [J]. Cells, 2019, 9(1).
[43] PARAMITA N P, ALEXANDER B, KUMAR B S. Mitophagy-driven
metabolic switch reprograms stem cell fate [J]. Cellular and
molecular life sciences : CMLS, 2019, 76(1).
[44] XIAO M, ZHANG J, CHEN W, et al. M1-like tumor-associated
macrophages activated by exosome-transferred THBS1 promote malignant
migration in oral squamous cell carcinoma [J]. Journal of
Experimental & Clinical Cancer Research, 2018, 37(1).
[45] LOCATI M, CURTALE G, MANTOVANI A. Diversity, Mechanisms, and
Significance of Macrophage Plasticity [J]. Annual Review of
Pathology: Mechanisms of Disease, 2020, 15(1).
[46] HE C, LARSON-CASEY J L, DAVIS D, et al. NOX4 modulates
macrophage phenotype and mitochondrial biogenesis in asbestosis [J].
JCI Insight, 2019, 4(16).
[47] SATU T, AMRO M, SANNA O, et al. Tumor microenvironment and
breast cancer survival: combined effects of breast fat, M2 macrophages
and hyaluronan create a dismal prognosis [J]. Breast cancer research
and treatment, 2020, 179(3).
[48] ZHANG Q, WANG H, MAO C, et al. Fatty acid oxidation contributes
to IL-1beta secretion in M2 macrophages and promotes macrophage-mediated
tumor cell migration [J]. Mol Immunol, 2018, 94: 27-35.
[49] JIWEI S, QINGMING T, SHAOLING Y, et al. F. nucleatum
facilitates oral squamous cell carcinoma progression via GLUT1-driven
lactate production [J]. EBioMedicine, 2023, 88.
[50] BIN G, LEILEI L, JIAPEI G, et al. M2 tumor-associated
macrophages produce interleukin-17 to suppress oxaliplatin-induced
apoptosis in hepatocellular carcinoma [J]. Oncotarget, 2017, 8(27).
[51] SHIELDS C W, EVANS M A, WANG L L-W, et al. Cellular backpacks
for macrophage immunotherapy [J]. Science Advances, 2020, 6(18).
[52] QUARANTA V, SCHMID M C. Macrophage-Mediated Subversion of
Anti-Tumour Immunity [J]. Cells, 2019, 8(7).
[53] CHEUNG P, YANG J, FANG R, et al. Progranulin mediates immune
evasion of pancreatic ductal adenocarcinoma through regulation of MHCI
expression [J]. Nature communications, 2022, 13(1): 156.
[54] VITALE I, MANIC G, COUSSENS L M, et al. Macrophages and
Metabolism in the Tumor Microenvironment [J]. Cell Metabolism, 2019,
30(1).
[55] GARTRELL R, MARKS D, HART T, et al. Quantitative Analysis of
Immune Infiltrates in Primary Melanoma [J]. Cancer immunology
research, 2018, 6(4): 481-93.
[56] ZAEEM N M, GUY B, BASSAM J. Targeting autophagy blocks melanoma
growth by bringing natural killer cells to the tumor battlefield
[J]. Autophagy, 2018, 14(4).
[57] GUERRIERO J. Macrophages: The Road Less Traveled, Changing
Anticancer Therapy [J]. Trends in molecular medicine, 2018, 24(5):
472-89.
[58] FU X T, SONG K, ZHOU J, et al. Tumor-associated macrophages
modulate resistance to oxaliplatin via inducing autophagy in
hepatocellular carcinoma [J]. Cancer Cell Int, 2019, 19: 71.
[59] JIEYU Z, LIN L, PEIYAO W, et al. Fusobacterium nucleatum
Accelerates Atherosclerosis via Macrophage-Driven Aberrant
Proinflammatory Response and Lipid Metabolism
 [J]. Frontiers
in Microbiology, 2022, 13.
[60] BASSAM J, MERIEM H, SANTIAGO P, et al. Firing up the cold
tumors by targeting Vps34 [J]. Oncoimmunology, 2020, 9(1).
[61] WANTING K, JIAMING C, CHIENCHIN C, et al. Autophagy drives
plasticity and functional polarization of tumor-associated macrophages
[J]. IUBMB life, 2021, 74(2).
[62] J C A, KATHARINA S A. Autophagy in the renewal, differentiation
and homeostasis of immune cells [J]. Nature reviews Immunology,
2019, 19(3).
[63] GUO Y, FENG Y, CUI X, et al. Autophagy inhibition induces the
repolarisation of tumour-associated macrophages and enhances
chemosensitivity of laryngeal cancer cells to cisplatin in mice [J].
Cancer Immunol Immunother, 2019, 68(12): 1909-20.
[64] DEGAO C, JING X, ROLAND F, et al. Chloroquine modulates
antitumor immune response by resetting tumor-associated macrophages
toward M1 phenotype [J]. Nature communications, 2018, 9(1).
[65] YONG L, FENGJUN C, MINGXING L, et al. Hydroxychloroquine
induced lung cancer suppression by enhancing chemo-sensitization and
promoting the transition of M2-TAMs to M1-like macrophages [J].
Journal of experimental & clinical cancer research : CR, 2018, 37(1).
[66] HSU S, CHEN Y, CHIANG H, et al. Rapamycin and
hydroxychloroquine combination alters macrophage polarization and
sensitizes glioblastoma to immune checkpoint inhibitors [J]. Journal
of neuro-oncology, 2020, 146(3): 417-26.
[67] SHIAU D, KUO W, DAVULURI G, et al. Hepatocellular
carcinoma-derived high mobility group box 1 triggers M2 macrophage
polarization via a TLR2/NOX2/autophagy axis [J]. Scientific reports,
2020, 10(1): 13582.
[68] JIANYE X, JIAN Z, ZONGPU Z, et al. Hypoxic glioma-derived
exosomes promote M2-like macrophage polarization by enhancing autophagy
induction [J]. Cell Death & Disease, 2021, 12(4).
[69] TSAI Y L, CHEN Y, CHEN Y C, et al. KDELC2 Upregulates
Glioblastoma Angiogenesis via Reactive Oxygen Species Activation and
Tumor-Associated Macrophage Proliferation [J]. Antioxidants (Basel),
2023, 12(4).
[70] JIN Z, SHEN C, ZHANG H, et al. Chinese medicine Xiaoshui
decoction inhibits malignant pleural effusion in mice and mediates
tumor-associated macrophage polarization by activating autophagy
[J]. Journal of Ethnopharmacology, 2020, 249(C).
[71] ZHUANG L, JUAN F W, QING C X, et al. Autophagy-based
unconventional secretion of HMGB1 in glioblastoma promotes
chemosensitivity to temozolomide through macrophage M1-like polarization
[J]. Journal of Experimental & Clinical Cancer Research, 2022,
41(1).
[72] JIA-HAU Y, WEI-CHIEH H, SHU-CHING L, et al. Metabolic
remodeling in tumor-associated macrophages contributing to antitumor
activity of cryptotanshinone by regulating TRAF6-ASK1 axis [J].
Molecular Therapy - Oncolytics, 2022, 26.
[73] HUADAN X, DONG L, JIAOYAN M, et al. The IL-33/ST2 axis affects
tumor growth by regulating mitophagy in macrophages and reprogramming
their polarization [J]. Cancer biology & medicine, 2021, 18(1).
[74] ZHI-FA W, HONGXIANG L, RONG G, et al. Tumor cell-released
autophagosomes (TRAPs) promote immunosuppression through induction of
M2-like macrophages with increased expression of PD-L1 [J]. Journal
for immunotherapy of cancer, 2018, 6(1).
[75] JINGYI Z, WEIYU W, QI L. Potential therapeutic targets in the
tumor microenvironment of hepatocellular carcinoma: reversing the
protumor effect of tumor-associated macrophages [J]. Journal of
Experimental & Clinical Cancer Research, 2021, 40(1).
[76] FU L-Q, DU W-L, CAI M-H, et al. The roles of tumor-associated
macrophages in tumor angiogenesis and metastasis [J]. Cellular
Immunology, 2020, 353(prepublish).
[77] CIANCIARUSO C, BELTRAMINELLI T, DUVAL F, et al. Molecular
Profiling and Functional Analysis of Macrophage-Derived Tumor
Extracellular Vesicles [J]. Cell Reports, 2019, 27(10).
[78] BO N, XUAN H, YEQIAN Z, et al. Tumor-associated
macrophage-derived GDNF promotes gastric cancer liver metastasis via a
GFRA1-modulated autophagy flux [J]. Cellular oncology (Dordrecht),
2023, 46(2).
[79] YUANYUAN G, WEI S, WUYUE G, et al. Long Noncoding RNA H19
Derived from M2 Tumor-Associated Macrophages Promotes Bladder Cell
Autophagy via Stabilizing ULK1 [J]. Journal of Oncology, 2022, 2022.
[80] KANGWU W, XIAO C. Autophagic tumor-associated macrophages
promote the endothelial mesenchymal transition in lung adenocarcinomas
through the FUT4/p-ezrin pathway [J]. Journal of thoracic disease,
2021, 13(10).
[81] DAVULURI G, CHEN C, CHIU Y, et al. Autophagy Drives Galectin-1
Secretion From Tumor-Associated Macrophages Facilitating Hepatocellular
Carcinoma Progression [J]. Frontiers in cell and developmental
biology, 2021, 9: 741820.
[82] ASHLEY O, P D N, LI S, et al. Dietary Protein Restriction
Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy
[J]. Clinical cancer research : an official journal of the American
Association for Cancer Research, 2018, 24(24).
[83] LUCY I, ALMUDENA S, FIONA C, et al. Blockade of insulin-like
growth factors increases efficacy of paclitaxel in metastatic breast
cancer [J]. Oncogene, 2018, 37(15).
[84] DUAN Q, ZHANG H, ZHENG J, et al. Turning Cold into Hot: Firing
up the Tumor Microenvironment [J]. Trends Cancer, 2020, 6(7):
605-18.
[85] CLAUDIA O, BLANCA A, MIGUEL P. Hot and Cold Tumors: Is Endoglin
(CD105) a Potential Target for Vessel Normalization? [J]. Cancers,
2021, 13(7).
[86] CHAEUK C, WONHYOUNG S, PRASHANTA S, et al. Crosstalks between
inflammasome and autophagy in cancer [J]. Journal of hematology &
oncology, 2020, 13(1).
[87] Y X, R C, H-M H. TLR and NLRP3 inflammasome-dependent innate
immune responses to tumor-derived autophagosomes (DRibbles) [J].
Cell death & disease, 2016, 7(8).
[88] KEISUKE Y, ANTHONY V, JULIAN Y, et al. Autophagy promotes
immune evasion of pancreatic cancer by degrading MHC-I [J]. Nature,
2020, 581(7806).
[89] JIEHUI D, AATISH T, IGOR D, et al. ULK1 inhibition overcomes
compromised antigen presentation and restores antitumor immunity in
LKB1-mutant lung cancer [J]. Nature Cancer, 2021, 2(5).
[90] NOMAN M Z, PARPAL S, MOER K V, et al. Inhibition of Vps34
reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1
immunotherapy [J]. Science Advances, 2020, 6(18).
[91] YUANYUAN Q, EUN C J, C. T J, et al. Autophagy inhibition by
targeting PIKfyve potentiates response to immune checkpoint blockade in
prostate cancer [J]. Nature Cancer, 2021, 2(9).
[92] ALISSAFI T, GOGAS H, VERGINIS P, et al. Autophagy orchestrates
the regulatory program of tumor-associated myeloid-derived suppressor
cells [J]. Journal of Clinical Investigation, 2018, 128(9).
[93] LAWSON K A, SOUSA C M, ZHANG X, et al. Functional genomic
landscape of cancer-intrinsic evasion of killing by T cells [J].
Nature: International weekly journal of science, 2020, 586(7827).
[94] M Y T, CLAUDIA R, ELIZABETH P, et al. Autophagy protects tumors
from T cell-mediated cytotoxicity via inhibition of TNFα-induced
apoptosis [J]. Science immunology, 2020, 5(54).
[95] JUAN D, KATE L R S, A. K E, et al. In vivo screens using a
selective CRISPR antigen removal lentiviral vector system reveal immune
dependencies in renal cell carcinoma [J]. Immunity, 2021, 54(3).
[96] KEISUKE Y, DOSUKE I, HIROYUKI K, et al. Targeting autophagy as
a therapeutic strategy against pancreatic cancer [J]. Journal of
gastroenterology, 2022, 57(9).
[97] ZHONG Z, SANCHEZ-LOPEZ E, KARIN M. Autophagy, Inflammation, and
Immunity: A Troika Governing Cancer and Its Treatment [J]. Cell,
2016, 166(2).
[98] SHARMA G, OJHA R, NOGUERA-ORTEGA E, et al. PPT1 inhibition
enhances the antitumor activity of anti-PD-1 antibody in melanoma
[J]. JCI Insight, 2020, 5(17).
[99] HADERK F, SCHULZ R, ISKAR M, et al. Tumor-derived exosomes
modulate PD-L1 expression in monocytes [J]. Science Immunology,
2017, 2(13).
[100] HONGLIN J, TRISTAN C, JOSEPH B, et al. Activating Immune
Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy
Inhibition, MEK blockade and CD40 Agonism [J]. Gastroenterology,
2021, 162(2).
[101] XU G, FENG D, YAO Y, et al. Listeria-based hepatocellular
carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage
polarization [J]. Oncogene, 2020, 39(7): 1429-44.
[102] TAN H Y, WANG N, MAN K, et al. Autophagy-induced RelB/p52
activation mediates tumour-associated macrophage repolarisation and
suppression of hepatocellular carcinoma by natural compound baicalin
[J]. Cell Death Dis, 2015, 6(10): e1942.
[103] XIU-TAO F, KANG S, JIAN Z, et al. Tumor-associated macrophages
modulate resistance to oxaliplatin via inducing autophagy in
hepatocellular carcinoma [J]. Cancer cell international, 2019,
19(1).