Acknowledgments
The authors thank the iExplore animal facility (IGF, Montpellier) and the Arpege platform (IGF, Montpellier) for the use of plate reader fluorimeter for cell-population BRET and FRET assay. The authors thank Philippe Marin, Jean-Philippe Pin, Laurent Prézeau, Charlotte Avet and Michel Bouvier for providing biosensors and helpful discussions. We are grateful to Charlotte Sarre for the mGlu5 receptor graphic design. This work was supported by the Agence Nationale de la Recherche (JP, ANR-22-CE16-0013 LEARN) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (JP, grant agreement No. 646788 VERTICAL CITY).