Total preschool population (N = 125) (a) NSRW (n = 47) (b) SRW (n = 78) p-value (a) vs (b) Total school-age population (n = 198) (c) NSA (n = 108) (d) SA (n = 90) p-value (c) vs (d)
Demographics Age, y Male gender Caucasian Birth weight, g Z-score for BMI 5 [4, 6] 84/125 (67.2) 91/119 (76.5) 3185 [2800, 3502] 0.3 [-0.5, 1.1] n’=124 5 [4, 6] 32/47 (68.1) 35/42 (83.3) 3380 [3102, 3550] 0.3 [-0.3, 0.8] n’=47 5 [4, 6] 52/78 (66.7) 56/77 (72.7) 3100 [2600, 3430] 0.4 [-0.6, 1.3] n’=77 0.23 0.99 0.99 0.0036 0.48 9 [ 8, 11] 112/170 (65.9) 104/158 (65.8) 3270 [2925, 3665] 0.7 [-0.3, 2.0] n’=163 9 [ 8.0, 10.2] 69/108 (63.9) 70/102 (68.6) 3305 [2900, 3715] 0.9 [-0.3, 2.0] n’=102 9 [ 9, 11] 43/62 (69.4) 34/56 (60.7) 3200 [2930, 3540] 0.5 [-0.4, 1.7] n’=61 0.12 0.58 0.41 0.27 0.32
Environment Rural or semi-rural home Mother smoked during pregnancy Second-hand smoke exposure Visible mold/dampness at home Pet ownership 56/125 (44.8) 17/125 (13.6) 18/122 (14.8) 26/124 (21.0) 57/125 (45.6) 23/47 (48.9) 4/47 (8.5) 1/47 (2.1) 4/46 (8.7) 19/47 (40.4) 33/78 (42.3) 13/78 (16.7) 17/75 (22.7) 22/78 (28.2) 38/78 (48.7) 0.59 0.31 0.0044 0.019 0.47 78/169 (46.2) 18/168 (10.7) 8/164 (4.9) 28/168 (16.7) 95/169 (56.2) 47/107 (43.9) 10/106 (9.4) 5/104 (4.8) 16/106 (15.1) 58/107 (54.2) 31/62 (50) 8/62 (12.9) 3/60 (5.0) 12/62 (19.4) 37/62 (59.7) 0.55 0.66 0.99 0.62 0.60
Associated allergic disorders Family atopy in 1 parent or sibling History of food allergy History of allergic rhinitis History of atopic dermatitis 102/120 (85.0) 18/120 (15.0) 61/124 (49.2) 42/125 (33.6) 40/46 (87.0) 7/46 (15.2) 27/46 (58.7) 16/47 (34.0) 62/74 (83.8) 11/74 (14.9) 34/78 (43.6) 26/78 (33.3) 0.47 0.99 0.15 0.99 138/160 (86.2) 30/166 (18.1) 127/170 (74.7) 58/170 (34.1) 87/102 (85.3) 14/106 (13.2) 79/108 (73.1) 29/108 (26.9) 51/58 (87.9) 16/60 (26.7) 48/62 (77.4) 29/62 (46.8) 0.82 0.051 0.66 0.014
Asthma outcomes Age at first wheeze (months) No. of admissions for asthma exacerbation in childhood Asthma exacerbation in the previous year ACT score Total PAQLQ score FEV1 pre-BD (Z-score) FEV1/FVC pre-BD (Z-score) ICS ICS doses (µg/d eq Budesonide) ICS + LABA 5 [2, 8] n’=104 1 [0, 4] n’=125 71/123 (57.7) 20 [16, 23] n’=119 - -0.1 [-0.9, 0.9] n’=77 -0.1 [-1.2, 0.7] n’=77 115/125 (92.0) 800 [400, 1600] n’=115 48/124 (38.7) 6 [3.8, 8.0] n’=36 0 [0, 1] n’=47 3/47 (6.4) 23 [22, 25] n’=43 - 0 [-0.5, 0.9] n’=37 -0.1 [-0.9, 0.4] n’=37 37/47 (78.7) 400 [400, 400] n’=37 13/46 (27.7) 4 [2.0, 8.2] n’=68 3 [0, 5] n’=78 68/76 (89.5) 18 [14, 21] n’=76 - -0.3 [-1.3, 0.9] n’=40 -0.2 [-1.4, 1.1] n’=40 78/78 (100.0) 1000 [800, 1837] n’=78 35/77 (45.5) 0.072 < 0.0001 < 0.0001 < 0.0001 - 0.35 0.85 < 0.0001 < 0.0001 0.074479 5 [2, 9] n’=120 0 [0, 2] n’=168 53/169 (31.4) 21 [17, 24] n’=170 6 [4.8, 6.8] n’=167 -0.1 [-1.2, 0.6] n’=160 -0.7 [-1.5, 0.1] n’=158 136/170 (80.0) 500 [400, 1000] n’=136 101/170 (59.4) 6 [2, 11] n’=73 0 [0, 1] n’=107 8/107 (7.5) 23 [20.0, 24.2] n’=108 6.2 [5.4, 6.8] n’=105 0.1 [-0.8, 0.8] n’=103 -0.6 [-1.2, 0.1] n’=101 74/108 (68.5) 400 [250, 500] n’=74 48/108 (44.4) 4 [2.0, 8.5] n’=47 2 [0, 5] n’=61 45/62 (72.6) 17 [13.2, 20.0] n’=62 5.2 [3.7, 6.4] n’=62 -0.7 [-1.9, 0.2] n’=57 -1.5 [-2.4, -0.1] n’=57 62/62 (100.0) 1000 [800, 1150] n’=62 53/62 (85.5) 0.13 < 0.0001 < 0.0001 < 0.0001 0.00086 0.00034 0.00057 < 0.0001 < 0.0001 < 0.0001
Allergic sensitization Atopy Total IgE (Ku/L) Blood eosinophil count (n/mm3) 65/106 (61.3) 89 [ 28.2, 317.2] n=114 250 [120, 500] n=101 30/43 (69.8) 129 [ 41.8, 428.2] n’=40 300 [135, 600] n’=39 35/63 (55.6) 84.5 [ 25.2, 235.8] n’=74 240 [105, 475] n’=62 0.20 0.24 0.40 125/152 (82.2) 283 [ 87.5, 691.5] n’=159 400 [200, 700] n’=124 78/97 (80.4) 300.5 [ 94.0, 676.8] n’=100 320 [200, 600] n’=77 47/55 (85.5) 239 [ 74.0, 811.5] n’=59 400 [195.5, 800.0] n’=47 0.57 0.70 0.41