Changes in the synaptic filtering at the lateral PP
It has been hypothesized that low-pass filtering of synaptic inputs to
the DG underlies the encoding information of auditory, olfactory, and
visual cues (Scullin and Partridge, 2012; Madar et al., 2019). In this
regard, frequency-dependent synaptic filtering of the LPP has been
thoroughly characterized in adult mice (Quintanilla et al., 2022). We
first confirmed that juvenile rats possess this physiological property;
then, we demonstrated that synaptic filtering in the LPP is drastically
altered in slices from MK-801-treated animals. Our experimental findings
and multiple theoretical models (Chance et al., 1998; Quintanilla et
al., 2022) imply that the diminished filtering capacity of the LPP
synapse may result from a decreased presynaptic release. The impaired
low-pass filtering capability of the LPP could represent the cellular
substrate that explains the abnormal processing of sensory information
conveyed by the LPP, which is excessively amplified in the DG of
schizophrenic individuals (Arnold, 1999; Prasad et al., 2004; Behrendt,
2016) instead of being properly filtered. Although appealing, this idea
requires experimental examination.