Statistical analysis
Group measures are numerically expressed as mean ± SEM. The violin plots
show the median, mean, first, and third quartiles. All statistical
comparisons were performed between control values and those obtained
from MK-801-treated animals, following the guidelines on experimental
design and analysis in pharmacology (Curtis et al., 2018). The normality
distribution of data was validated with the Kolmogorov–Smirnov test
(P = 0.05). No outliers were removed from the data. The
comparability among experimental conditions was assessed by two-tailed
paired (or unpaired) Student’s t-test, Mann-Whitney test, Wilcoxon test,
Kruskal-Wallis test, or two-way repeated-measures (RM) analysis of
variance (ANOVA), as appropriate. The Holm–Šidák post-hoc or Dunn’s
post-hoc test was used for multiple comparisons among experimental
groups, only when F achieved minimal statistical significance. For all
the experiments, data were considered significant
if P < 0.05.