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\begin{document}

\title{Medium- and long-chain triacylglycerol in human breast milk and
association with maternal dietary patterns}



\author[1]{Jingru Gong}%
\author[1]{Lei Wang}%
\author[2]{Xingguo Wang}%
\author[1]{Wei Wei}%
\affil[1]{Jiangnan University}%
\affil[2]{Affiliation not available}%


\vspace{-1em}



  
  \date{May 26, 2024}


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\selectlanguage{english}
\begin{abstract}
This study aims to investigate the influences of maternal dietary
patterns on the triacylglycerol (TAG) composition, particular medium-
and long-chain triacylglycerol (MLCT) in human breast milk. A total of
180 Chinese human breast milk samples were collected and divided into
three dietary patterns groups accounting to semi-quantitative food
intake frequency questionnaire and a 24-hour dietary recall. Using high
performance liquid chromatography combined with quadrupole
time-of-flight mass spectrometry, 108 TAGs were identified and
quantified. In breast milk samples, MLCTs accounted for 25.76 \% (median
of 24.63\%; 95\% CI: 24.60, 26.92) of the total TAGs. In human breast
milk, the main type of MLCT is TAGs esterified with one medium-chain
fatty acid and two long-chain fatty acids (MLL type) which accounted for
\textasciitilde{}81\% of total MLCTs. Among the molecular species of
MLCT, O-P-La, O-L-La, and O-L-M are the three most abundant
configurations in MLCT (2.28\%, 2.17\%, and 2.01\% of total TAGs,
respectively). MLCT in breast milk was positively correlated with the
energy supply ratio of carbohydrates (P = 0.205), which was
significantly higher than that of the other two groups (P = -0.150 and
-0.232).%
\end{abstract}%



\sloppy


\textbf{1. Introduction}

Human milk is recognized as the best food for newborns, rich in lipids,
proteins, carbohydrates, and other micronutrients to ensure the enough
energy and nutrients for newborns for growth and development (Harding et
al., 2017). The World Health Organization (WHO) recommends exclusive
breastfeeding for the first six months of life of infants (Eidelman et
al., 2012). Lipids are important nutrients in breast milk, accounting
for about 3-5\% and providing 50-60\% of the newborn's energy
(Demmelmair and Koletzko, 2018). Human milk lipids are reported as
variable influenced by many factors for example individuals, lactational
period, maternal dietary \emph{etc} (Grunewald et al., 2019; Burianova
et al., 2019; Gridneva et al., 2022; Ye et al., 2021).

The fatty acid (FAs) profiles in human breast milk have been
well-studied worldwide (Liu et al., 2018). Recent studies show that
triacylglycerols (TAGs) in human breast milk have unique molecular
structure and showing important roles for infant lipid digestion and
metabolism. Previously, we analyzed the TAG composition of Chinese human
milk, found a group of TAG containing both medium-chain fatty acids
(MCFAs) and long-chain fatty acids (LCFAs) esterified at one glycerol
backbone, namely medium- and long-chain triacylglycerol (MLCT) (Yuan et
al., 2020). According to the number of medium-chain fatty acid (MCFA)
and long-chain fatty acids (LCFAs) on the glycerol backbone, MLCT can be
divided into two types,the MLCT esterified with one MCFA and two LCFAs
are the MLL type; and the MLCT esterified with two MCFAs and one LCFA
are the MML type. In human milk, MLCT types of TAGs contains
approximately 40 kinds of TAGs, accounting for 20-30\% of total TAG
(Zhang et al., 2021; Yuan et al., 2021). There are obvious differences
of the MLCT content and molecular species in lipids between human milk.

Compared with LCT, MLCT has not only long-chain fatty acids, but also
medium-chain fatty acids. Due to the presence of MCFA, it is more
conducive to the direct absorption and utilization of infants, MLCT will
have higher lipolysis degree as well as release higher levels of free
fatty acid in infant intestinal digestion (Yuan et al., 2020; Wang et
al., 2022), therefore MLCT is conducive to the digestion and absorption
of lipids, providing fast energy (Yu et al., 2022a). In addition, MLCT
has more incorporation of long-chain fatty acids than MCT, allowing it
to provide the physiological activities of the body (Lee et al., 2022).

Previous studies show that FAs in human milk are highly influenced by
the maternal diet (Ward et al., 2021; Wang et al., 2010). The content of
protein, and lactose in breast milk was not obviously affected by the
breast milk diet, but the fatty acids in breast milk were affected by
the mother 's immediate diet (Aumeistere et al., 2019). There are also
studies of Nigeri mothers that high carbohydrate intake leads to higher
MCFA in breast milk, while excessive intake of fat may lead to lower
levels of MCFA (VanderJagt et al., 2000), Sudan (Nyuar et al., 2010),
and Egypt (Bakry et al., 2021) show high content of 12:0 and 14:0, which
were approximately 20\% of total fatty acids. Current studies have shown
that MCFAs are affected by dietary structure, but the relationship
between TAG containing MCFAS and dietary patterns in breast milk is
rarely studied.

This study aims to analysis the correlation between MLCT content \&
molecular species and maternal dietary patterns. This study collected
mature breast milk samples and dietary intake data of healthy Chinese
lactating women 30-90 days \emph{postpartum} . A total of 180 volunteer
mothers were divided into three groups fat group (\textgreater{} 30
energy \%, \emph{n} = 60), carbohydrate group (\textgreater{} 50 energy
\%, \emph{n} = 60), and protein group (\textgreater{}15 energy
\%,\emph{n} = 60) according to Yang (Yang, 2018). recommendations. TAGs
were identified and quantified using High Performance Liquid
Chromatography-Mass Spectrometry (LC-MS) following our previous studies.
The composition of MLCTs in breast milk and their relationship with
nutrient energy supply ratio were clarified, which provided scientific
basis for developing novel structured lipids used in infant formula.

\textbf{2. Materials and methods}

\textbf{2.1. Materials and Reagents}

All lactating mothers in this study were obtained from the Maternal and
Child Health and Family Planning Service Center of Jiangning District,
Nanjing, Jiangsu Province, China. From November 2018 to January 2019,
breast milk of 121 eligible healthy lactating mothers was included in
this study. The project has been approved by the Human Research Ethics
Committee of Nanjing Medical University and registered as
ChiCTR1800020179 in clinicaltrials.gov. Each participant provided oral
and written informed consent. Inclusion criteria: (1) 20-40 years old
healthy lactating mothers, 30-50 days postpartum exclusive
breastfeeding; (2) singleton pregnancy, full-term delivery ([?] 37 weeks
of gestation), birth weight [?] 2500 g, [?] 4000 g infants. Mothers with any
infectious disease, severe malignant disease, malnutrition, or mental
illness; people diagnosed with breast diseases such as mastitis; or
people with pregnancy complications such as gestational hypertension and
diabetes were excluded. Mothers who had a history of drinking and
smoking during pregnancy and lactation, vegetarians, mothers who
consumed fatty acid supplements during lactation, or who participated in
other studies in the past 30 days were also excluded.

The mixed TAGs standards (8:0, 10:0, 12:0, 14:0 and 16:0, 17811-1AMP)
were purchased from Sigma-Aldrich Limited (Shanghai, China). High
performance liquid chromatography grade \emph{n} -hexane, acetonitrile,
and \emph{iso} -propanol were purchased from Shanghai Bailingwei
Technology Co., Ltd. (China, Shanghai). Ammonia, ethanol, anhydrous
ethyl ether (boiling point of 30 to 60 ), and petroleum ether were
purchased from Chemical Reagent Co., Ltd. (Shanghai, China).

\textbf{2.2. Study design}

\textbf{Dietary assessment.} The semi-quantitative Food Frequency
Questionnaire (FFQ) report asks all mothers to record their usual
dietary intake in the past month. The three components of a food list,
how often you eat a certain food, and the amount of food you eat at a
time make up the FFQ. A total of 156 food items are on the list, mainly
divided into 13 categories: staple foods, vegetables, fruits, aquatic
products, livestock and poultry, poultry, eggs, milk and its products,
soybeans and their products, nuts, edible oils, processed foods,
seasonings, and beverages. This FFQ was validated with 3-day dietary
records from lactating mothers. This information is collected by trained
graduate students themselves. The original data of food amount in FFQ
were input into EpiData software for verification. Then the daily intake
of food group, energy and nutrition was calculated. The database was
based on the \emph{Chinese Food Composition Table (6th edition)} (Yang,
2018) and combined with the values obtained from the USDA National
Nutrient Database for Standard Reference (Burke et al., 2016).

\textbf{Sample collection.} Breast milk (10-15 mL) was collected from
each mother between 07:30 a.m. and 09:00 a.m. Breast milk samples are
collected in a polypropylene tube and no preference for one breast. All
sampling procedures are carried out to ensure that the light is avoided.
The samples were quickly stored in a hospital refrigerator at 4 , and
then transported to a laboratory refrigerator in a lightproof container
with ice, stored at -20  for one week, and then stored at -70  until
analysis.

\textbf{Quality control.} Experts were invited to review and revise the
questionnaire on baseline characteristics to ensure its scientificity.
All researchers received rigorous training and evaluation before
conducting the study. After the experiment was completed, baseline
information and dietary data were examined with the participants. In
order to improve the accuracy of dietary data in FFQ, participants
estimated the size of the food component with the help of a food map
with sufficient visual reference. Breast milk samples were collected in
strict accordance with standard sampling techniques. The instruments and
containers used for sampling were disinfected and used once. TAG
concentration in breast milk was detected by the same instrument and the
same batch of reagents. The main data were input into EpiData software
twice by two trained researchers to verify its accuracy. In statistical
analysis, the appropriate statistical methods are selected strictly
according to the statistical requirements and data types.

\textbf{2.3. Lipid extraction from breast milk}

Human milk fat was extracted using the classical R\selectlanguage{ngerman}öse--Gottlieb
method(Crocker et al., 1955). Briefly, 1 mL of ammonium hydroxide
solution was added into 5 mL breast milk. The mixture was heated to 65 ±
5 \selectlanguage{english} using electric heating constant temperature oscillation water bath
for 20 min. After cool to room temperature, 5 mL anhydrous ethanol, 10
mL anhydrous ether, and 10 mL petroleum ether were added into the
mixture with full shaking and stand for 2 h. The supernatant was
separated from water and then collected. The solvent of the supernatant
was removed by nitrogen. The above operation was repeated for the second
extraction. The resulting supernatant was combined with the first
extract, and the solvent was blown dry to constant weight with nitrogen
to obtain human milk fat. The human milk fat content was calculated with
the results were expressed as g/100 mL.

\textbf{2.4. Triacylglycerol composition analysis}

Extracted human milk fat was dissolved in \emph{n} -hexane to obtain a
concentration of 0.3 mg/mL. The composition of TAGs in human milk fat
was determined using UPLC-Q-TOF-MS following our previous studies (Zhang
et al., 2021). Column was BEHC18 (2.1 mm x 50 mm, 1.9 \selectlanguage{greek}μ\selectlanguage{english}m, Waters, USA).
The UPLC condition was set as: column temperature is 45 , injection
temperature of 20 and injection volume of 1 \selectlanguage{greek}μ\selectlanguage{english}L. Mobile phase A was
acetonitrile / isopropanol (1:9, \emph{v} /\emph{v} ), and mobile phase
B was acetonitrile/water (4:6, \emph{v} /\emph{v} ). Both mobile phases
contain ammonium acetate (10 mmol/L). Mobile phase of 70\% A was used as
the starting gradient for 1 min; then increase to 87\% A at 30 min and
hold for 1 min; then return to initial 70\% A at 32 min and maintain for
4 min. The flow rate was 300 \selectlanguage{greek}μ\selectlanguage{english}L/min. After each sample, the column was
washed with 5\% mobile phase A for 5 min before starting detection for
the next sample.

Q-TOF-MS condition was set as 10 mmol/L of ammonium formate in methanol
as inclusion with a shunt ratio of 1:3 and a flow rate of 0.2 mL/min;
electrospray ionization source (ESI), positive ion mode; capillary
voltage of 3.5 kV, cone hole voltage of 30 V; ion source temperature 100
, desolvent temperature 400; collision gas is argon, flow rate of 50
L/h; dessolvated gas is nitrogen, flow rate of 700 L/h. The molecular
weight scans ranged from 200 to 1500 m/z with a scan time of 0.2 s and a
time interval of 0.02 s. TAGs were qualitative according to mass
spectrometry information and quantified by area normalization. Relative
concentrations were calculated by dividing the peak area of a single TAG
by the sum of all peak areas within the sample.

\textbf{2.5. Statistical analysis}

Data from the UPLC-Q-TOF-MS were analyzed using the MassLynx V4.1
software (Milford, MA, USA). Data results are represented as mean \selectlanguage{ngerman}±
standard deviation. Statistical analysis was performed using IBM SPSS
Statistics 25 software (New York, USA). Groups were significant by the
Duncan test in analysis of variance (ANOVA), which were considered
statistically different at \emph{P} \textless{} 0.05. The Pearson's
correlation test was used to determine the relationship between breast
milk triacylglycerol composition and maternal dietary intake. Boxplots
were plotted using GraphPad prism 9.0 (California, USA). Correlation
heat maps were plotted using TBtools software (Guangdong, China).
Principal component analysis (PCA) plots were plotted using SIMCA 14.1
software (Demo Umetrics, Umea, Sweden).

\textbf{3. Results and discussion}

\textbf{3.1. Socio-demographic characteristics of milk sample donors}

In this study, a total of 180 breast milk samples were analyzed in this
study. The demographic characteristics of the groups according to
dietary patterns are shown in Table 1. According to the energy supply
ratio of the three major nutrients of the mother, 180 cases of mature
milk were divided into three groups (fat group, carbohydrate group, and
protein group), with 60 samples in each group. The average ages of
mothers in three group were all approximately 30, and the pregnancy
periods were approximately 39 weeks. The rate of natural delivery was
slightly higher than that of cesarean section. All infants were
full-term infants with birth weight of approximately 3.5 kg. Male
infants were more than female infants. It can be seen from the table
that there is no significant difference between mothers and newborns in
each group. There was no significant difference in total energy intake
among the three groups of mothers.

\textbf{3.2. Total energy intake to nutrient energy ratio}

The purpose of this study was to explore the effect of nutrient energy
supply ratio on TAG composition of breast milk by food frequency
questionnaire. The total energy intake and nutrient supply ratio of the
three groups are shown in Table 1. The total daily energy intake in the
fat group was 2106.07 kcal in the mothers, 2189.21 kcal in the
carbohydrate group, and 2246.35 kcal in the protein group. There was no
significant difference in total energy intake among the three groups
(\emph{P} \textgreater{} 0.05). Each group had and only one nutrient
function ratio was significantly higher than the other two groups. The
fat energy ratio and protein energy ratio were significantly different
among the three groups of mothers (\emph{P} \textless{} 0.05). The
carbohydrate energy ratio of mothers in carbohydrate group was
significantly higher than that in fat group and protein group, but there
was no significant difference between fat group and protein group.

Referring to the 2022 Dietary Guidelines for Chinese Residents
(\emph{Dietary Guidelines for Chinese Residents} , 2022), the total
energy intake of all mothers was lower than the dietary energy
requirement of lactating mothers (2300 kcal/day). Only the carbohydrate
intake of lactating mothers in the carbohydrate group
(\textasciitilde{}57\%) was within the acceptable range of
macronutrients (50-60\%), and the carbohydrate intake of the other two
groups (\textasciitilde{}45\% and \textasciitilde{}43\%) was below the
lower limit of the range. In addition, the fat intake of lactating
mothers in the three groups was higher than the upper limit of the
acceptable range of macronutrients (20-30\%), especially the fat intake
of lactating mothers in the fat group and the protein group was too high
(\textasciitilde{}40\% and \textasciitilde{}36\%).

Lipids are known as a major source of energy, and a diet composed mainly
of lipids can provide more energy for future generations (Mehta, 2008).
A mother 's high-fat diet increases the concentration of milk fat,
especially LCFA and MCFA, leading to a fuller transfer of this
macronutrient to the infant (Seet et al., 2015). In an early report, it
was observed that a high-fat diet can promote the development of the
hippocampus by stimulating neurogenesis and reducing apoptosis (Li et
al., 2017). However, some studies have shown that maternal high prenatal
intake of sugar and prenatal or postpartum intake of saturated fatty
acids are associated with increased obesity (Gomes et al., 2018) in
offspring. But this excessive fat intake is consistent with two studies
(Chen et al., 2012; Tian et al., 2019; Hui-Min et al., 2019) conducted
in southeastern and northeastern China, which may be related to the
nature of postpartum eating habits in China. This postpartum practice
refers to increasing the consumption of high-fat and protein-rich foods,
such as chicken soup and pig hoof soup \emph{etc} . It shows that
Chinese lactating women need to follow a more balanced diet, especially
emphasizing less fat intake.

\textbf{3.3. Compositional characteristics of breast milk
triacylglycerols}

In this study, UPLC-Q-TOF-MS was used to identify the species and
content of TAGs in 180 breast milk, and a total of 108 TAGs were
identified based on the m/z values of precursors and fragments. As
shown, Table 2 shows the TAG in breast milk and 95\% confidence
intervals (95\% CI) in 3 groups, of which 41 TAG were significantly
different (\emph{P} \textless{} 0.05). The highest content of TAG in
mature breast milk is O-P-L (median of 17.09\%; 95\% CI: 16.83, 17.63),
followed by O-P-O (median of 12.84\%; 95\% CI: 12.40, 13.20), which is
consistent with many previous research conclusions. Studies on TAGs in
breast milk in Western countries have shown that the highest content of
TAG is O-P-P, which may be related to the different preferences of
various countries for edible oils, genetic and environmental factors.
Pons et al. (Morera Pons et al., 2000) detected the highest content of
two TAGs in Spanish breast milk as O-P-O and O-P-L, which accounted for
more than 49 \% of the total, and dominated in transition milk (34\%),
and mature milk (42\%). And Ten-Domenech et al. (Ten-Domenech et al.,
2015) detected 42 TAGs in mature breast milk in Spain, of which O-P-O
had the highest content, followed by O-P-L and O-P-La. Zou et al. (Zou
et al., 2013) detected 22 TAGs in Danish breast milk, of which the
highest content was O-P-O (about 22\%), followed by O-P-L (about 17\%)
and O-P-La (about 10\%). Different from Western countries, Zhu et al.
(Zhu et al., 2021) studied breast milk from 8 different cities in China.
A total of 66 TAGs were detected in mature breast milk, and the maximum
values of O-P-O and O-P-L were 15.7 \% and 11.88 \%, respectively. The
difference of TAG content in breast milk in different countries may be
related to the detection methods used by researchers and the dietary
habits and genes of mothers in different regions, which also reflects
the diversity and complexity of TAG composition in breast milk.

This study shows that the highest content of TAG is O-P-L in Chinese
breast milk which fits the previous studies (Zhang et al., 2021; Xinghe
et al., 2019). This may be due to the high consumption level of soybeans
and soybean products in Chinese mothers (Wang et al., 2023). Soybean oil
ranks first in the total consumption of Chinese cooking (Fang and
Beghin, 2002). The content of O-P-L in breast milk of protein group
(\textasciitilde{}18\%) was significantly higher than that of
carbohydrate group (\textasciitilde{}17\%) (P \textless{} 0.05). In
addition, the content of O-P-O in breast milk of the protein group was
13.52\%, which was significantly higher than that of the carbohydrate
group (\textasciitilde{}12\%) (P \textless{} 0.05). It can be seen that
the breast milk of the protein group is rich in
saturated-unsaturated-unsaturated (SUU) type, especially
1,3-diunsaturated fatty acid-2-palmitate (UPU) type TAG. However,
because there are few studies on the relationship between the
composition of the three major nutrients and the composition of
triglycerides in breast milk, it is not clear why the content of SUU
type TAG in protein group is high.

Among the 41 TAGs with significant differences, 22 were MLCT type.
L-L-Ca (median of 0.19\%; 95\% CI: 0.19, 0.22) and O-L-Ca (median of
0.64\%; 95\% CI: 0.62, 0.68) are typical MLL-type TAG. As shown in Table
3, the contents of MLCT for example L-L-Ca and O-L-Ca in breast milk of
carbohydrate group were 0.24\% and 0.71\%, respectively, which were
significantly higher than those of fat group and protein group
(\emph{P}\textless{} 0.05), and their contents were 0.17\% and 0.60\%.
Similarly, the contents of L-L-La (median of 0.70\%; 95\% CI: 0.73,
0.85), O-L-La (median of 2.06\%; 95\% CI: 2.05,2.28) and L-Po-M (median
of 0.12\%; 95\% CI: 0.12, 0.14) in breast milk of carbohydrate group
(0.96\%, 2.46\% and 0.15\%) were significantly higher than those of fat
group (0.75\%, 2.1\% and 0.13\%) and protein group (0.66\%, 1.93\% and
0.12\%) (\emph{P} \textless{}0.05). In addition, it can also be seen
that the content of MML type TAG such as L-La-Ca (median of 0.22\%; 95\%
CI: 0.22, 0.25), L-M-Ca (median of 0.16\%; 95\% CI: 0.16, 0.18) and
L-La-La (median of 0.36\%; 95\% CI: 0.36, 0.42) and UUU such as L-L-L
(median of 1.71\%; 95\% CI: 1.83, 2.20) and O-L-L (median of 3.82\%;
95\% CI: 3.94, 4.79) in the breast milk of the carbohydrate group was
also significantly higher than that of the other two groups
(\emph{P}\textless{} 0.05). This study confirmed that the higher the
proportion of carbohydrate energy supply in mothers in Nanjing, China,
the higher the content of MLCT in breast milk.

The contents of SSU such as O-P-P (median of 2.89\%; 95\% CI: 2.96,
3.28) and S-O-P (median of 3.58\%; 95\% CI: 3.44, 3.86) in breast milk
of the fat group were slightly higher, which were 3.31 \% and 4.01 \%,
respectively. Table 2 shows that the composition and composition of TAGs
in breast milk fat are correlated with maternal diet. This observation
should inform future research and can be taken into account when
discussing diet with breastfeeding mothers.

\textbf{3.4. Comparation of triacylglycerol composition in breast milk
of different dietary groups}

In order to intuitively show the difference of MLCT composition and UPU
composition in different groups of breast milk, their compositions were
made into a box line diagram, as shown in Fig.1. According to Fig.1, the
carbohydrate group had the highest MLCT (\textasciitilde{}27\%) and the
lowest UPU (\textasciitilde{}38\%) in breast milk. On the contrary, the
content of UPU (\textasciitilde{}41\%) in breast milk of the proteome
group was higher than that of other groups, and the content of MLCT
(\textasciitilde{}23\%) was lower than that of other groups. This is
consistent with the positive correlation of the protein energy ratio
with the amount of UPU in the breast milk. The total content of MLCT and
UPU in breast milk of the three groups was very close, maintained at
\textasciitilde{}65\%, and there was no significant difference,
indicating that the total content of MLCT and UPU in breast milk was not
affected by dietary structure.

Principal component analysis (PCA) was performed on the MLCT components
in breast milk of the three groups to further show the differences of
MLCT components in breast milk under different dietary patterns. From
Fig.2, it can be seen that although some breast milk samples from
different dietary groups are clustered together, their distribution is
significantly different, indicating that there are significant
differences in the composition of MLCT in breast milk from different
dietary patterns. For example, the breast milk samples of carbohydrate
group were mainly distributed in the first, third and fourth quadrants,
while the other two groups were distributed in four quadrants. The
distribution of carbohydrate group was significantly different from that
of the other two groups, indicating that the composition of MLCT in
carbohydrate group was significantly different from that of the other
two groups. The fat group was very close to the protein group, almost
overlapping, both concentrated in the second and third quadrants, but
the breast milk samples of fat group were more dispersed. The difference
in the composition of MLCT in breast milk is related to the dietary
structure of the mother, but further studies are needed to clarify.

The 21 kinds of TAGs with a content greater than 1 \% in the three
groups of breast milk were made into a cluster heat map to show the
differences more intuitively in TAG content in breast milk of different
dietary groups. The results are shown in Fig.3, and the differences in
TAG composition in breast milk of different dietary groups were further
analyzed. As can be seen in Fig.3, the carbohydrate group breast milk is
rich in MLCT such as O-L-La, O-P-La, and O-L-M, the fat group breast
milk is rich in SSU type, such as O-P-P, S-P-L and S-P-O, while the
protein group breast milk is rich in SUU type especially UPU type, such
as O-P-L and O-P-O. About 70 \% of palmitic acid is distributed in
the\emph{sn} -2 position of TAG, and stearic acid, oleic acid, linoleic
acid and linolenic acid are mainly distributed in the \emph{sn} -1,3
position, which is conducive to the absorption and utilization of fat
and minerals (Watkins et al., 2003). However, due to the current
research on the relationship between dietary structure and breast milk
TAG composition, it is not clear why there are differences in breast
milk TAGs in different dietary groups. Future studies should focus on
the effect of maternal diet on TAG composition in breast milk to better
guide the diet of lactating women. This study confirmed that the energy
supply ratio of carbohydrate in Chinese mothers was positively
correlated with the content of MLCT in breast milk (\emph{P} \textless{}
0.05), the energy supply ratio of protein was positively correlated with
the content of UPU (\emph{P} \textless{} 0.01), and the energy supply
ratio of fat was positively correlated with the content of SSU (\emph{P}
\textless{} 0.05).

\textbf{3.5. Correlation between energy supply ratio of three major
nutrients and triacylglycerol composition of breast milk}

Pearson correlation coefficient analysis was performed on the energy
supply ratio of the three nutrients and breast milk TAGs. As shown in
Tables 3, MMM in breast milk was weakly positively correlated with
carbohydrate energy supply ratio (\emph{P} \textless{} 0.05), MML was
strongly negatively correlated with protein energy supply ratio
(\emph{P} \textless{} 0.05), and weakly positively correlated with
carbohydrate energy supply ratio (\emph{P} \textless{} 0.05). The
contents of MLCT and MLL in breast milk were strongly positively
correlated with carbohydrate energy supply ratio (\emph{P} \textless{}
0.05), strongly negatively correlated with protein energy supply ratio
(\emph{P} \textless{} 0.05), and weakly negatively correlated with fat
energy supply ratio (\emph{P} \textless{} 0.05). It also can be seen
from Table 4 that the content of 8:0-MLL, 10:0-MLL and 12:0-MLL in
breast milk of carbohydrate group was significantly higher than that of
protein group (\emph{P} \textless{} 0.05). In particular, 12:0-MLL in
breast milk was strongly positively correlated with carbohydrate energy
ratio (\emph{P} \textless{} 0.01), strongly negatively correlated with
protein energy ratio (\emph{P} \textless{} 0.01), and weakly negatively
correlated with fat energy ratio (\emph{P} \textless{} 0.05). UPU was
strongly positively correlated with protein energy ratio
(\emph{P}\textless{} 0.05), strongly negatively correlated with
carbohydrate energy ratio (\emph{P} \textless{} 0.05), and weakly
positively correlated with fat energy ratio (\emph{P} \textless{} 0.05).

The total content of MLCT and UPU in breast milk was not affected by
dietary structure, indicating that the total content of MLCT and UPU in
breast milk was relatively stable. Our previous study (Yu et al., 2022b)
also pointed out that the sum of MLCT and UPU was not affected by region
and lactation and remained stable. By changing the proportion of the
three major nutrients in the diet, changes in the TAG composition of
breast milk can be achieved, especially MLCT type TAG. In the face of
infants with poor absorption of medium and long chain fatty acids or
feeding intolerance, beneficial consequences can be produced by
adjusting the mother 's diet.

\textbf{4. Conclusion}

This study introduced a previously developed UPLC-Q-TOF-MS method for
the qualitative and quantitative detection of TAGs in 180 Chinese breast
milk samples. According to the proportion of the three major nutrients
(fat, carbohydrate, and protein) in the maternal diet, they were divided
into three groups to explore the potential correlation between fat
composition in Chinese breast milk and maternal dietary factors.
Lactation is a physiological state, which poses a major challenge to
maternal energy homeostasis due to its high demand for energy.

Maternal carbohydrate energy ratio was positively correlated with the
amount of MLCT in breast milk (\emph{P} \textless{} 0.05), protein with
UPU triglycerides (\emph{P} \textless{} 0.01) and fat with SSU
(\emph{P}\textless{} 0.05). However, the total content of MLCT and UPU
were not significantly associated with the energy supply ratio of the
three major nutrients. Comparison of the triglyceride composition in
different groups showed that the total amount of MLCT in breast milk was
significantly higher in the carbohydrate group than in the other two
groups (\emph{P} \textless{} 0.05). Further, the content of 8:0-MLL,
10:0-MLL and 12:0-MLL in the carbohydrate group was significantly higher
than that in the proteome (\emph{P} \textless{} 0.05). The total amount
of UPU in the proteome breast milk was significantly higher than that in
the carbohydrate and fat groups (\emph{P} \textless{} 0.05). There was
no significant difference in total content of MLCT and UPU in different
groups.

There are two limitations of the current study that should be deeper
studied in the future. Firstly, in the dietary recall survey, many
participants were unable to identify specific cooking vegetable oil
types or report the use of mixed oils; which limits the further analysis
of the effect of each vegetable oil on the fat composition of breast
milk. Secondly, the recruitment of lactating women only focused on the
Jiangsu Province which lacking representation. Therefore, a diverse and
larger population needs to be studied in the future to confirm these
results, considering possible interactions and confounding factors. The
digestive characteristics of different types of MLCT in the
gastrointestinal tract of infants also need further study.

\textbf{Acknowledgement}

This work was supported by National Key R\&D Program of China
(2021YFD2100700).

\textbf{Abbreviation used}

TAG, triacylglycerol; MLCT, medium- and long-chain triacylglycerol; MLL,
one medium-chain fatty acid and two long-chain fatty acids; MML\selectlanguage{english},two
medium-chain fatty acid and one long-chain fatty acids; FA, fatty acid;
MCFA, medium-chain fatty acid; LCFA, long-chain fatty acids; LC-MS, high
performance liquid Chromatography-Mass Spe; FFQ, food frequency
questionnaire; UPLC, Ultra performance liquid chromatography; Q-TOF-MS,
Quadrupole-time of flight-mass spectrometry; ESI, electrospray
ionization source; APCA, principal component analysis; SUU,
saturated-unsaturated-unsaturated; UPU, 1,3-diunsaturated fatty
acid-2-palmitate.

\textbf{Conflict of interest}

The authors declare that they have no known competing financial
interests or personal relationships that could have appeared to
influence the work reported in this paper.

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\textbf{Table 1.} Demographic characteristics of groups by dietary
pattern.\selectlanguage{english}
\begin{longtable}[]{@{}llll@{}}
\toprule
Characteristics & Fat group & Carbohydrate group & Protein
group\tabularnewline
\midrule
\endhead
\emph{n}= & 60 & 60 & 60\tabularnewline
\emph{Maternity information} & \emph{Maternity information} &
\emph{Maternity information} & \emph{Maternity
information}\tabularnewline
Gestational age (weeks) & 39.29 \selectlanguage{ngerman}± 1.06 & 39.48 \selectlanguage{ngerman}± 1.34 & 39.49 \selectlanguage{ngerman}±
1.12\tabularnewline
Maternal age (years) & 29.49 \selectlanguage{ngerman}± 3.74 & 30.03 \selectlanguage{ngerman}± 4.03 & 30.57 \selectlanguage{ngerman}±
3.62\tabularnewline
Delivery type (vaginal/caesarean) & 33/27 & 38/22 & 35/25\tabularnewline
\emph{Baby information} & \emph{Baby information} & \emph{Baby
information} & \emph{Baby information}\tabularnewline
Baby birth weight (kg) & 3.43 \selectlanguage{ngerman}± 0.40 & 3.39 \selectlanguage{ngerman}± 0.42 & 3.40 \selectlanguage{ngerman}±
0.42\tabularnewline
Baby gender (male/female) & 35/25 & 39/21 & 32/28\tabularnewline
\emph{Energy ratios of three nutriments}\textsuperscript{a} &
\emph{Energy ratios of three nutriments}\textsuperscript{a} &
\emph{Energy ratios of three nutriments}\textsuperscript{a} &
\emph{Energy ratios of three
nutriments}\textsuperscript{a}\tabularnewline
Energy (kcal/d) & 2106.07 \selectlanguage{ngerman}± 439.81 & 2189.21 \selectlanguage{ngerman}± 411.14 & 2246.35 \selectlanguage{ngerman}±
463.28\tabularnewline
Fat (g) & 92.03 \selectlanguage{ngerman}± 23.19 & 71.25 \selectlanguage{ngerman}± 14.68 & 89.95 \selectlanguage{ngerman}± 17.65\tabularnewline
Fat (energy \%) & 39.67 \selectlanguage{ngerman}± 5.32\textsuperscript{a} & 29.42 \selectlanguage{ngerman}±
3.22\textsuperscript{c} & 36.46 \selectlanguage{ngerman}± 4.72\textsuperscript{b}\tabularnewline
Carbohydrate (g) & 236.55 \selectlanguage{ngerman}± 61.93 & 312.22 \selectlanguage{ngerman}± 63.52 & 249.02 \selectlanguage{ngerman}±
69.62\tabularnewline
Carbohydrate (energy \%) & 44.82 \selectlanguage{ngerman}± 6.43\textsuperscript{b} & 56.97 \selectlanguage{ngerman}±
3.78\textsuperscript{a} & 43.84 \selectlanguage{ngerman}± 5.97\textsuperscript{b}\tabularnewline
Protein (g) & 87.59 \selectlanguage{ngerman}± 21.07 & 81.06 \selectlanguage{ngerman}± 19.6 & 116.25 \selectlanguage{ngerman}±
26.15\tabularnewline
Protein (energy \%) & 15.51 \selectlanguage{ngerman}± 1.84\textsuperscript{b} & 13.61 \selectlanguage{ngerman}±
1.66\textsuperscript{c} & 19.70 \selectlanguage{ngerman}± 2.13\textsuperscript{a}\tabularnewline
\bottomrule
\end{longtable}\selectlanguage{ngerman}

Different lower-case letters indicate significant differences between
different dietary groups, \emph{P} \textless{}0.05.
\textsuperscript{a}The contribution to total energy intake by
macronutrient (mean daily intake). In China, the recommendations are
20-30\% from fat and 50-65\% from carbohydrates of total energy intake.
For protein intake, lactating mothers are 25 g/d more than the reference
value of the same age group, and the recommended intake is 80 g/d.

\textbf{Table 2.} Triacylglycerol composition (wt\%) of in human breast
milk.\selectlanguage{english}
\begin{longtable}[]{@{}lllll@{}}
\toprule
\begin{minipage}[b]{0.19\columnwidth}\raggedright\strut
TAGs\strut
\end{minipage} & \begin{minipage}[b]{0.19\columnwidth}\raggedright\strut
Fat group (\emph{n}=60)\strut
\end{minipage} & \begin{minipage}[b]{0.19\columnwidth}\raggedright\strut
Carbohydrate group (\emph{n}=60)\strut
\end{minipage} & \begin{minipage}[b]{0.19\columnwidth}\raggedright\strut
Protein group (\emph{n}=60)\strut
\end{minipage} & \begin{minipage}[b]{0.19\columnwidth}\raggedright\strut
Median, 95 CI (\emph{n}=180)\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
La-La-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 (0.03, 0.05)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
M-La-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 (0.04, 0.05)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
La-La-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.07\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 (0.05, 0.07)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-P-Bu\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.03\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.02\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 (0.03, 0.04)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-P-Bu\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 (0.09, 0.11)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-La-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 (0.08, 0.10)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
M-La-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.13\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.18 \selectlanguage{ngerman}± 0.16\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 (0.13, 0.17)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-Bu\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.03\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 (0.03, 0.03)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-La-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.23 \selectlanguage{ngerman}± 0.12\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 \selectlanguage{ngerman}± 0.13\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.20 \selectlanguage{ngerman}± 0.10\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.22 (0.22, 0.25)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-La-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.42 \selectlanguage{ngerman}± 0.18\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.46 \selectlanguage{ngerman}± 0.20\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.39 \selectlanguage{ngerman}± 0.16\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.40 (0.39, 0.45)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-M-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.12\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 \selectlanguage{ngerman}± 0.07\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 (0.12, 0.15)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
M-M-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.25 \selectlanguage{ngerman}± 0.20\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.29 \selectlanguage{ngerman}± 0.25\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.23 \selectlanguage{ngerman}± 0.13\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.22 (0.23, 0.29)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-Co\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.04\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.04\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.03\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 (0.04, 0.06)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-M-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.16 \selectlanguage{ngerman}± 0.08\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.20 \selectlanguage{ngerman}± 0.10\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.07\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.16 (0.16, 0.18)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-La-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.38 \selectlanguage{ngerman}± 0.18\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.46 \selectlanguage{ngerman}± 0.22\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.35 \selectlanguage{ngerman}± 0.16\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.36 (0.36, 0.42)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-M-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.31 \selectlanguage{ngerman}± 0.15\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.34 \selectlanguage{ngerman}± 0.17\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 \selectlanguage{ngerman}± 0.12\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.29 (0.29, 0.34)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-La-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.54 \selectlanguage{ngerman}± 0.27\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.59 \selectlanguage{ngerman}± 0.29\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.52 \selectlanguage{ngerman}± 0.24\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.51 (0.51, 0.59)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
Po-M-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.07\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.08\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 \selectlanguage{ngerman}± 0.06\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 (0.13, 0.15)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-M-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 (0.06, 0.08)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-La-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 (0.05, 0.07)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-P-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 (0.07, 0.08)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-M-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.27 \selectlanguage{ngerman}± 0.18\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.29 \selectlanguage{ngerman}± 0.23\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.24 \selectlanguage{ngerman}± 0.12\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.22 (0.24, 0.29)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
M-M-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 (0.01, 0.02)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-Cy\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.05\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 \selectlanguage{ngerman}± 0.05\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.04\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 (0.08, 0.09)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-Po-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.03\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.02\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 (0.04, 0.05)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-P-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.47 \selectlanguage{ngerman}± 0.42\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.51 \selectlanguage{ngerman}± 0.51\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.35 \selectlanguage{ngerman}± 0.37\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.47 (0.38, 0.51)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-M-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.26 \selectlanguage{ngerman}± 0.23\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 \selectlanguage{ngerman}± 0.28\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.19 \selectlanguage{ngerman}± 0.20\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.25 (0.21, 0.28)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-P-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.40 \selectlanguage{ngerman}± 0.53\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.44 \selectlanguage{ngerman}± 0.60\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.34 \selectlanguage{ngerman}± 0.50\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.30 (1.31, 1.47)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-M-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.74 \selectlanguage{ngerman}± 0.31\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.76 \selectlanguage{ngerman}± 0.35\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.66 \selectlanguage{ngerman}± 0.25\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.66 (0.68, 0.77)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-P-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.16 \selectlanguage{ngerman}± 0.09\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.16 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.07\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 (0.14, 0.17)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-M-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.09\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 (0.13, 0.16)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-P-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.23 \selectlanguage{ngerman}± 0.13\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.23 \selectlanguage{ngerman}± 0.15\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.21 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.20 (0.21, 0.24)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-M-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 (0.04, 0.05)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-L-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.20 \selectlanguage{ngerman}± 0.12\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.24 \selectlanguage{ngerman}± 0.13\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.17 \selectlanguage{ngerman}± 0.11\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.19 (0.19, 0.22)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.65 \selectlanguage{ngerman}± 0.21\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.71 \selectlanguage{ngerman}± 0.21\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.60 \selectlanguage{ngerman}± 0.18\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.64 (0.62, 0.68)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-Po-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.03\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 \selectlanguage{ngerman}± 0.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 \selectlanguage{ngerman}± 0.03\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 (0.09, 0.10)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-L-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.05\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.06\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 \selectlanguage{ngerman}± 0.04\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 (0.13, 0.15)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-O-Ca\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.04\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 \selectlanguage{ngerman}± 0.05\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 \selectlanguage{ngerman}± 0.03\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 (0.09, 0.10)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-P-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.69 \selectlanguage{ngerman}± 0.59\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.90 \selectlanguage{ngerman}± 0.71\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.58 \selectlanguage{ngerman}± 0.53\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.65 (1.63, 1.82)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-M-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.20 \selectlanguage{ngerman}± 0.08\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.22 \selectlanguage{ngerman}± 0.09\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.18 \selectlanguage{ngerman}± 0.07\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.19 (0.19, 0.21)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-P-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.31 \selectlanguage{ngerman}± 0.95\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.35 \selectlanguage{ngerman}± 1.01\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.17 \selectlanguage{ngerman}± 0.92\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.09 (2.14, 2.42)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-M-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.69 \selectlanguage{ngerman}± 0.40\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.68 \selectlanguage{ngerman}± 0.38\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.58 \selectlanguage{ngerman}± 0.31\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.58 (0.60, 0.70)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-P-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.33 \selectlanguage{ngerman}± 0.19\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.30 \selectlanguage{ngerman}± 0.17\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.30 \selectlanguage{ngerman}± 0.17\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 (0.28, 0.34)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-M-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 (0.06, 0.07)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-P-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 (0.07, 0.09)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-Ln-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.06\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.06\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.04\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 (0.04, 0.06)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-L-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.75 \selectlanguage{ngerman}± 0.35\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.96 \selectlanguage{ngerman}± 0.49\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.66 \selectlanguage{ngerman}± 0.34\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.70 (0.73, 0.85)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.10 \selectlanguage{ngerman}± 0.68\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.46 \selectlanguage{ngerman}± 0.85\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.93 \selectlanguage{ngerman}± 0.65\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.06 (2.05, 2.28)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-Po-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 \selectlanguage{ngerman}± 0.05\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.06\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 \selectlanguage{ngerman}± 0.04\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 (0.12, 0.14)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
Po-Po-Po\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.01\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.01\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.01\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 (0.02, 0.02)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
Ed-M-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.00\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.01\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.00\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 (0.02, 0.02)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-O-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.33 \selectlanguage{ngerman}± 0.38\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.42 \selectlanguage{ngerman}± 0.43\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.28 \selectlanguage{ngerman}± 0.36\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.31 (1.28, 1.40)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-Po-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 (0.10, 0.11)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-L-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.50 \selectlanguage{ngerman}± 0.14\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.53 \selectlanguage{ngerman}± 0.16\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.48 \selectlanguage{ngerman}± 0.14\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.49 (0.48, 0.52)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-P-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.79 \selectlanguage{ngerman}± 0.23\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.85 \selectlanguage{ngerman}± 0.26\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.76 \selectlanguage{ngerman}± 0.22\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.78 (0.77, 0.84)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-O-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.40 \selectlanguage{ngerman}± 0.16\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.38 \selectlanguage{ngerman}± 0.16\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.39 \selectlanguage{ngerman}± 0.18\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.35 (0.36, 0.41)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-P-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.50 \selectlanguage{ngerman}± 0.59\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.41 \selectlanguage{ngerman}± 0.58\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.44 \selectlanguage{ngerman}± 0.68\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.31 (1.36, 1.54)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-P-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.15 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 \selectlanguage{ngerman}± 0.07\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 (0.13, 0.15)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
P-P-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 (0.09, 0.11)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-P-Pa\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 (0.01, 0.02)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
Et-L-La\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 \selectlanguage{ngerman}± 0.02\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 (0.01, 0.02)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-Ln-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.03\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.03\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 (0.02, 0.03)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-L-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.71 \selectlanguage{ngerman}± 0.30\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.83 \selectlanguage{ngerman}± 0.37\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.68 \selectlanguage{ngerman}± 0.29\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.69 (0.69, 0.79)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.01 \selectlanguage{ngerman}± 0.50\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.07 \selectlanguage{ngerman}± 0.56\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.95 \selectlanguage{ngerman}± 0.55\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.98 (1.93, 2.09)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-Po-Po\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.4 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.41 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.39 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.38 (0.39, 0.41)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-P-Po\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.33 \selectlanguage{ngerman}± 0.09\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.34 \selectlanguage{ngerman}± 0.10\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.33 \selectlanguage{ngerman}± 0.09\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.32 (0.32, 0.35)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-O-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.48 \selectlanguage{ngerman}± 0.33\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.36 \selectlanguage{ngerman}± 0.32\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.48 \selectlanguage{ngerman}± 0.45\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.41 (1.38, 1.49)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-P-Po\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.83 \selectlanguage{ngerman}± 0.18\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.76 \selectlanguage{ngerman}± 0.16\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.84 \selectlanguage{ngerman}± 0.21\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.79 (0.78, 0.84)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-L-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.26 \selectlanguage{ngerman}± 0.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 \selectlanguage{ngerman}± 0.09\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.27 (0.26, 0.28)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-P-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.09 \selectlanguage{ngerman}± 0.50\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.95 \selectlanguage{ngerman}± 0.49\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.19 \selectlanguage{ngerman}± 0.53\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.01 (2.00, 2.15)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-O-M\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.50 \selectlanguage{ngerman}± 0.17\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.42 \selectlanguage{ngerman}± 0.15\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.49 \selectlanguage{ngerman}± 0.16\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.44 (0.45, 0.50)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-P-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.31 \selectlanguage{ngerman}± 1.15\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.79 \selectlanguage{ngerman}± 0.96\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.25 \selectlanguage{ngerman}± 1.05\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.89 (2.96, 3.28)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-P-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.30 \selectlanguage{ngerman}± 0.16\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.25 \selectlanguage{ngerman}± 0.14\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.29 \selectlanguage{ngerman}± 0.14\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.25 (0.26, 0.30)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-Pa\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 (0.05, 0.06)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-Ha-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 \selectlanguage{ngerman}± 0.07\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 \selectlanguage{ngerman}± 0.07\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 (0.09, 0.12)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-Ha-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 (0.04, 0.05)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-L-Po\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.26 \selectlanguage{ngerman}± 0.12\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 \selectlanguage{ngerman}± 0.12\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 \selectlanguage{ngerman}± 0.11\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.28 (0.26, 0.29)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-Ln-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.56 \selectlanguage{ngerman}± 0.25\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.59 \selectlanguage{ngerman}± 0.26\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.58 \selectlanguage{ngerman}± 0.23\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.58 (0.54, 0.61)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-Po\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.82 \selectlanguage{ngerman}± 0.25\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.87 \selectlanguage{ngerman}± 0.25\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.81 \selectlanguage{ngerman}± 0.25\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.86 (0.80, 0.87)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-L-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
6.61 \selectlanguage{ngerman}± 1.93\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
7.09 \selectlanguage{ngerman}± 2.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
6.63 \selectlanguage{ngerman}± 1.90\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
6.82 (6.48, 7.07)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
17.05 \selectlanguage{ngerman}± 2.73\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
16.67 \selectlanguage{ngerman}± 2.67\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
17.97 \selectlanguage{ngerman}± 2.63\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
17.09 (16.83, 17.63)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-O-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
13.13 \selectlanguage{ngerman}± 2.89\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
11.76 \selectlanguage{ngerman}± 2.41\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
13.52 \selectlanguage{ngerman}± 2.43\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
12.84 (12.40, 13.20)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-L-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
4.35 \selectlanguage{ngerman}± 0.96\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.90 \selectlanguage{ngerman}± 0.80\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
4.48 \selectlanguage{ngerman}± 0.81\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
4.26 (4.11, 4.38)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-O-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
4.01 \selectlanguage{ngerman}± 1.61\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.12 \selectlanguage{ngerman}± 1.11\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.82 \selectlanguage{ngerman}± 1.34\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.58 (3.44, 3.86)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-S-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.10\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.08\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 \selectlanguage{ngerman}± 0.08\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 (0.11, 0.14)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-He\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 (0.02, 0.02)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-Ha\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 (0.06, 0.08)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-O-Ha\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 (0.04, 0.04)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-L-Ln\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.20 \selectlanguage{ngerman}± 0.18\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.27 \selectlanguage{ngerman}± 0.28\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.19 \selectlanguage{ngerman}± 0.18\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.17 (0.19, 0.25)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
L-L-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.88 \selectlanguage{ngerman}± 1.16\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.34 \selectlanguage{ngerman}± 1.39\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.83 \selectlanguage{ngerman}± 1.18\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.71 (1.83, 2.20)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-L-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.98 \selectlanguage{ngerman}± 2.71\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
5.16 \selectlanguage{ngerman}± 3.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.96 \selectlanguage{ngerman}± 2.71\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.82 (3.94, 4.79)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-O-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.76 \selectlanguage{ngerman}± 2.67\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.05 \selectlanguage{ngerman}± 2.90\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.46 \selectlanguage{ngerman}± 2.94\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.92 (2.67, 3.51)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
Et-O-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.29 \selectlanguage{ngerman}± 1.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.30 \selectlanguage{ngerman}± 1.06\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.10 \selectlanguage{ngerman}± 0.96\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
1.22 (1.08, 1.38)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-L-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.70 \selectlanguage{ngerman}± 1.47\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.77 \selectlanguage{ngerman}± 1.49\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.49 \selectlanguage{ngerman}± 1.30\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.26 (2.45, 2.87)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-O-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.04 \selectlanguage{ngerman}± 1.14\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.99 \selectlanguage{ngerman}± 1.16\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
3.28 \selectlanguage{ngerman}± 1.27\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
2.98 (2.92, 3.28)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
O-O-O\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.82 \selectlanguage{ngerman}± 0.56\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.79 \selectlanguage{ngerman}± 0.57\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.75 \selectlanguage{ngerman}± 0.55\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.66 (0.71, 0.87)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-S-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.64 \selectlanguage{ngerman}± 0.32\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.57 \selectlanguage{ngerman}± 0.32\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.64 \selectlanguage{ngerman}± 0.39\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.57 (0.57, 0.67)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-O-O\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.80 \selectlanguage{ngerman}± 0.38\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.69 \selectlanguage{ngerman}± 0.30\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.87 \selectlanguage{ngerman}± 0.37\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.73 (0.74, 0.84)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
E-O-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.02\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.03\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 (0.04, 0.05)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
S-S-O\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.13 \selectlanguage{ngerman}± 0.08\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.09 \selectlanguage{ngerman}± 0.07\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 \selectlanguage{ngerman}± 0.08\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 (0.10, 0.13)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
DHA-L-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 \selectlanguage{ngerman}± 0.01\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 \selectlanguage{ngerman}± 0.02\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.00 (0.01, 0.01)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
Et-O-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.04\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.03\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.05 \selectlanguage{ngerman}± 0.04\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 (0.04, 0.05)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
De-O-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.08\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.09\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.07 \selectlanguage{ngerman}± 0.07\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 (0.06, 0.08)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
E-O-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.11 \selectlanguage{ngerman}± 0.14\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.12 \selectlanguage{ngerman}± 0.20\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.19\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.06 (0.10, 0.15)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
Da-O-P\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.08 \selectlanguage{ngerman}± 0.14\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.10 \selectlanguage{ngerman}± 0.23\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.14 \selectlanguage{ngerman}± 0.26\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 (0.08, 0.14)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
DHA-O-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.02 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.04 \selectlanguage{ngerman}± 0.04\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 (0.03, 0.04)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
DHA-S-L\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 \selectlanguage{ngerman}± 0.03\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.03 \selectlanguage{ngerman}± 0.05\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
0.01 (0.02, 0.03)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
MLCT\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
25.82 \selectlanguage{ngerman}± 7.53\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
27.35 \selectlanguage{ngerman}± 8.64\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
24.12 \selectlanguage{ngerman}± 7.13\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
24.63 (24.60, 26.92)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
MLL-MLCT\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
20.88 \selectlanguage{ngerman}± 5.46\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
21.98 \selectlanguage{ngerman}± 6.28\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
19.67 \selectlanguage{ngerman}± 5.52\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
20.36 (19.98, 21.70)\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
MML-MLCT\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
4.95 \selectlanguage{ngerman}± 2.17\textsuperscript{ab}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
5.37 \selectlanguage{ngerman}± 2.49\textsuperscript{a}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
4.45 \selectlanguage{ngerman}± 1.74\textsuperscript{b}\strut
\end{minipage} & \begin{minipage}[t]{0.17\columnwidth}\raggedright\strut
4.55 (4.60, 5.24)\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}

Different lower-case letters indicate significant differences between
different dietary groups, \emph{P} \textless{}0.05. Abbreviations of
fatty acids: Bu: 4:0; Co: 6:0; Cy: 8:0; Ca: 10:0; La: 12:0; M: 14:0; Mo:
14:1; P: 16:0; Po: 16:1; S: 18:0; O: 18:1; L: 18:2; Ln: 18:3; E: 20:0;
Eo: 20:1; Ed: 20:2; Et: 20:3; ARA: 20:4; EPA: 20:5; Da:22:1; Dt: 22:4;
De:22:4; DPA: 22:5; DHA: 22:6.

\textbf{Table 3.} Pearson correlation coefficients of the energy and
three nutriments with TAGs profiles by fatty acyl chain-length in human
breast milk.\selectlanguage{english}
\begin{longtable}[]{@{}lllll@{}}
\toprule
TAGs & Energy & Fat & Carbohydrates & Protein\tabularnewline
\midrule
\endhead
& (kcal/d) & (energy \%) & (energy \%) & (energy \%)\tabularnewline
MMM & 0.131 & -0.135 & 0.158\textsuperscript{*} & -0.141\tabularnewline
MLCT & 0.014 & -0.150\textsuperscript{*} & 0.205\textsuperscript{**} &
-0.232\textsuperscript{**}\tabularnewline
MLL-MLCT & 0.017 & -0.155\textsuperscript{*} & 0.212\textsuperscript{**}
& -0.240\textsuperscript{**}\tabularnewline
MML-MLCT & 0.005 & -0.128 & 0.175\textsuperscript{*} &
-0.197\textsuperscript{**}\tabularnewline
8:0-MLL & -0.003 & -0.167\textsuperscript{*} & 0.201\textsuperscript{**}
& -0.188\textsuperscript{*}\tabularnewline
10:0-MLL & 0.000 & -0.164\textsuperscript{*} & 0.218\textsuperscript{**}
& -0.238\textsuperscript{**}\tabularnewline
12:0-MLL & 0.036 & -0.204\textsuperscript{**} &
0.264\textsuperscript{**} & -0.277\textsuperscript{**}\tabularnewline
14:0-MLL & 0.009 & 0.036 & 0.077 & -0.127\tabularnewline
LLL & -0.018 & 0.151\textsuperscript{*} & -0.205\textsuperscript{**} &
0.229\textsuperscript{**}\tabularnewline
\bottomrule
\end{longtable}

*, \emph{P} \textless{}0.05; **,\emph{P} \textless{}0.01. M,
medium-chain fatty acid; L, long-chain fatty acid.

\textbf{Legends to Figures} :

\textbf{Fig. 1.} Contents (\%) of medium- and long-chain
triacylglycerol, di-unsaturated fatty acyl-palmitoyl-glycerols in human
breast milk of different dietary pattern.

Different lower-case letters indicate significant differences between
different dietary groups, \emph{P} \textless{}0.05.

\textbf{Fig. 2.} Principal component analysis of medium- and long-chain
triacylglycerol in human breast milk from different dietary pattern
groups.

\textbf{Fig. 3.} Cluster heat map of triacylglycerols (1\% of total
triacylglycerols) in human breast milk from different dietary pattern
groups.

\textbf{Fig. 1.}



\textbf{Fig. 2.}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image2/image2}

\end{center}
\end{figure}

\textbf{Fig. 3.}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image3/image3}

\end{center}
\end{figure}

\selectlanguage{english}
\FloatBarrier
\end{document}

