Funding

This work was supported by an intramural grant from the Ludwig Institute for Cancer Research (to LLV and ELF); the U.S. National Cancer Institute (CA70269 to ELF); the Canadian Institutes of Health Research (grants MA-13647, MOP-49396, CRN-83320 to ELF). The funders of the study had no involvement in study design; in the collection, analysis, and interpretation of data; neither in the writing of the report; and in the decision to submit the article. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.