Survival Analysis
The incidence rates of outcomes are presented as cases per 100
patient-years. The cumulative incidence of outcomes was estimated using
the Kaplan–Meier method. The difference between eligible and ineligible
patients with CHADS2 scores ≥2 was assessed using the
log-rank test. The effects of the ineligibility of patients on outcomes
were estimated using Cox proportional hazards models to calculate the
hazard ratio (HR) and 95% confidence interval. Statistical significance
was set at P <0.05 for all analyses. We presented only
unadjusted HR because the effects of ineligibility on the outcomes
reflected the integrated impact of many variables in ineligible
patients.
In addition, we added patients with CHADS2 scores
<2 to the group of ineligible patients and compared them with
the eligible patients regarding baseline characteristics and outcomes as
part of the sensitivity analysis.