Survival Analysis
The incidence rates of outcomes are presented as cases per 100 patient-years. The cumulative incidence of outcomes was estimated using the Kaplan–Meier method. The difference between eligible and ineligible patients with CHADS2 scores ≥2 was assessed using the log-rank test. The effects of the ineligibility of patients on outcomes were estimated using Cox proportional hazards models to calculate the hazard ratio (HR) and 95% confidence interval. Statistical significance was set at P <0.05 for all analyses. We presented only unadjusted HR because the effects of ineligibility on the outcomes reflected the integrated impact of many variables in ineligible patients.
In addition, we added patients with CHADS2 scores <2 to the group of ineligible patients and compared them with the eligible patients regarding baseline characteristics and outcomes as part of the sensitivity analysis.