Data Collection and Definitions
Trained clinical research coordinators reviewed and collected relevant
clinical information, including patient characteristics, laboratory
data, risk of ischemic stroke (CHADS2 score), and major
bleeding (HAS-BLED score) at baseline and relevant medications directly
from medical charts at baseline and at 1, 2, 3, and 4 years of
follow-up. Definitions of the baseline characteristics have been
previously described.14 The CHADS2score was developed to estimate the stroke risk in patients with
NVAF,15 and the HAS-BLED score was developed to
predict major bleeding in patients receiving anticoagulation
therapy.16