Conflict of interest
Dr Shinichiro Ueda reports a research grant from Bristol Myers Squibb and a lecturer’s fee from Kowa. Dr Takeshi Morimoto reports lecturer’s fees from AstraZeneca, Bristol-Myers Squibb, Daiichi Sankyo, Japan Lifeline, Kowa, Toray, and Tsumura; manuscript fees from Bristol-Myers Squibb and Kowa; advisory board for Novartis and Teijin.