|
PP group
(n=78)
|
Non-PP group
(n=78)
|
P value
|
Male (%) |
62 (79.5) |
61 (78.2) |
1.000 |
Age (year) |
77.5 (70.0, 83.0) |
76.0 (65.0, 86.0) |
0.942 |
BMI (kg/m2) |
25.0 (22.7, 27.4) |
22.5 (20.8, 25.4) |
0.002 |
SOFA score |
8.0 (6.0, 9.0) |
7.50 (6.0, 9.0) |
0.858 |
APACHE Ⅱ |
22.0 (16.3, 27.0) |
22.0 (18.0, 28.0) |
0.865 |
The main reasons for entering the ICU (%) |
|
|
|
Mainly due to COVID-19 infection |
35 (44.9) |
23 (29.5) |
0.076 |
Chronic disease exacerbation |
42 (53.8) |
51 (65.4) |
|
Trauma |
1 (1.3) |
4 (5.1) |
|
Intubated (%) |
66 (84.6) |
70 (89.7) |
0.472 |
Confirmed COVID-19 (%) |
60 (76.9) |
66 (84.6) |
0.310 |
Infection with sepsis (%) |
4 (5.1) |
4 (5.1) |
1.000 |
PEEP (cmH2O)a
|
8.5 (6.3, 10.0) |
5.0
(5.0, 7.0) |
<0.001 |
Respiratory Rate (breaths/min)a
|
16.0 (15.0, 20.0) |
15.0 (15.0, 15.0) |
<0.001 |
Tidal volume (ml)a
|
456.5 (392.5, 557.3) |
452.0
(409.0, 528.0) |
0.541 |
Peak airway pressure (cmH2O)a
|
23.0
(18.3, 26.0) |
20.0 (16.0, 24.0) |
0.007 |
Cydn (ml/cmH2O)a
|
32.6 (23.3, 41.2) |
31.5 (25.6,
40.7) |
0.892 |
Underlying disease (%) |
|
|
|
Pre-existing pulmonary disease |
30 (38.5) |
27 (34.6) |
0.739 |
Hypertension |
47 (60.3) |
41 (52.6) |
0.419 |
Diabetes |
24 (30.8) |
22 (28.2) |
0.861 |
Cardiovascular disease |
15 (19.2) |
14 (17.9) |
1.000 |
Cerebrovascular disease |
15 (19.2) |
18 (23.1) |
0.695 |
Malignant tumor |
19 (24.4) |
10 (12.8) |
0.100 |
Hepatitis |
6 (7.7) |
6 (7.7) |
1.000 |
Chronic kidney disease |
11 (14.1) |
12 (15.4) |
1.000 |
Chest CT (%) |
|
|
|
Pulmonary plaques or Ground-glass opacity |
58 (84.1) |
62 (86.1) |
0.916 |
Pulmonary fibrosis |
13 (18.8) |
19 (26.4) |
0.385 |
Pulmonary consolidation |
9 (13.0) |
9 (12.5) |
1.000 |
Medication use (%)b |
|
|
|
Antibiotic |
76 (97.4) |
45 (57.7) |
<0.001 |
Anti COVID-19 |
39 (50.0) |
21 (26.9) |
0.005 |
Immunoglobulin |
35 (44.9) |
6 (7.7) |
<0.001 |
Dexamethasone |
71 (91.0) |
58 (74.4) |
0.011 |
Norepinephrine |
78 (100.0) |
63 (80.8) |
<0.001 |
Blood gas indicators |
|
|
|
PaO2/FiO2 ratio (mmHg) |
125.5 (104.3,
169.0) |
212.5 (130.5, 289.5) |
<0.001 |
FiO2 (%) |
60.0 (45.8, 80.0) |
50.0 (40.0, 61.0) |
0.003 |
LAC (mmol/L) |
2.1 (1.6, 2.8) |
2.3 (1.6, 3.2) |
0.433 |
Inflammation |
|
|
|
CRP (mg/L) |
65.6 (18.4, 129.5) |
64.1 (27.5, 133.9) |
0.414 |
PCT (ng/ml) |
0.4 (0.1, 2.7) |
1.1 (0.4, 3.1) |
0.036 |
Blood system |
|
|
|
D-D (mg/L) |
2.6 (1.4, 7.4) |
2.5 (1.6, 8.3) |
0.889 |
WBC (×109/L) |
10.1 (7.8, 12.9) |
8.9 (6.4, 13.6) |
0.562 |
LYM (×109/L) |
0.5 (0.3, 0.7) |
0.5 (0.3, 1.0) |
0.328 |
Hb (g/L) |
122.0 (105.3, 138.5) |
116.5 (90.3, 130.3) |
0.034 |
PLT (109/L) |
162.5 (110.8, 199.8) |
156.0 (106.5,
216.0) |
0.728 |
Cardiac function |
|
|
|
BNP (pg/ml) |
1537.0 (768.3, 3479.5) |
1672.0 (472.5, 5370.5) |
0.928 |
TnT (ng/ml) |
0.04 (0.02, 0.10) |
0.05 (0.03, 0.12) |
0.103 |
LDH (U/L) |
516.0 (418.3, 657.0) |
386.0 (276.0, 610.0) |
0.014 |
Liver function |
|
|
|
ALT (U/L) |
27.0 (16.5, 43.5) |
25.5 (16.0, 38.8) |
0.725 |
AST (U/L) |
39.0 (27.5, 59.5) |
44.0 (27.0, 69.0) |
0.508 |
TBIL (μmol/L) |
11.0 (7.3, 17.0) |
12.1 (8.5, 14.9) |
0.523 |
Renal function |
|
|
|
Cr (μmol/L) |
97.5 (72.3, 201.5) |
112.0 (70.5, 186.3) |
0.989 |
Urea (mmol/L) |
11.7 (8.0, 19.4) |
12.2 (7.9, 18.0) |
0.844 |
eGFR [ml/(min×1.73m2)] |
60.6 (26.9, 81.9) |
50.1
(27.0, 86.3) |
0.976 |