Results
Our approach correctly identified SARS-CoV-2 and VSV-G receptors ACE2
and LDLR, respectively and distinguished genes associated with
retroviral reporter expression from envelope-mediated entry. Moreover,
the CRE-Gag fusion/flox reporter increased the screen specificity for
viral entry associated genes. Validation of a few hits demonstrates that
this approach distinguishes envelope-specific host factors from genes
affecting reporter expression.