Figure 3: Genome wide CRISPR screen against pseudoviruses reveals host factors necessary for entry into target cells. Volcano plot of negative Log (RRA) versus Log (fold change) of the A)SARS-CoV-2-Spike screen, B) VSVG-mNG screen, and C)the VSVG-Cre screen. The circled genes are highlighted based on biological function and subsequent analysis. D) The top 15 genes in VSVG-mNG plotted versus the top 15 genes in VSVG-CRE by negative Log (RRA). E) The top 15 genes in VSVG-mNG plotted versus the top 15 genes in Spike-mNG by negative Log (RRA).