Abbreviations: LBS, liquid-based screening; HRHPV, 14 high-risk types human papillomavirus test; HPV 16/18+, human papillomavirus types 16 and/or 18 positive results; HPV HR12+, human papillomavirus 12 high-risk types other than types 16 and 18 positive results; DS, p16/Ki67 dual staining test; LBC, liquid-based cytology; NILM, negative for intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; ASC-H+, atypical squamous cells-cannot exclude HSIL or worse; LSIL/CIN1, histologic low-grade squamous intraepithelial lesion; HSIL/CIN2+, histologic high-grade squamous intraepithelial lesion with a quantification of cervical intraepithelial neoplasia in grade 2 or worse; HSIL/CIN3+, histologic high-grade squamous intraepithelial lesion with a quantification of cervical intraepithelial neoplasia in grade 3 or worse; min, minimum; max, maximum; *, % of HSIL/CIN2+.

Estimated colposcopy outcomes in different triage strategies for HPV 16/18 positive women in primary HPV-based screening

In the study, triage model M1 required 152 colposcopies, 0 cases were missed and 43 HSIL/CIN2+ cases were detected, in triage model M1A 95/1/42, and in triage model M2 92/1/42, respectively. The missed HSIL/CIN2+ cases were caused by no indications for colposcopy according to the management applied for each of the models. The full results, including PPV values, for the 3 studied models and all the results sets are shown in Table 2.

Tab. 2. HSIL/CIN2+ reporting rates and PPVs for detection of HSIL/CIN2+ in HPV 16/18+ cases in the compared triage models.