Abbreviations: LBS, liquid-based screening; HRHPV, 14 high-risk types
human papillomavirus test; HPV 16/18+, human papillomavirus types 16
and/or 18 positive results; HPV HR12+, human papillomavirus 12 high-risk
types other than types 16 and 18 positive results; DS, p16/Ki67 dual
staining test; LBC, liquid-based cytology; NILM, negative for
intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of
undetermined significance; LSIL, low-grade squamous intraepithelial
lesion; ASC-H+, atypical squamous cells-cannot exclude HSIL or worse;
LSIL/CIN1, histologic low-grade squamous intraepithelial lesion;
HSIL/CIN2+, histologic high-grade squamous intraepithelial lesion with a
quantification of cervical intraepithelial neoplasia in grade 2 or
worse; HSIL/CIN3+, histologic high-grade squamous intraepithelial lesion
with a quantification of cervical intraepithelial neoplasia in grade 3
or worse; min, minimum; max, maximum; *, % of HSIL/CIN2+.
Estimated colposcopy outcomes in different triage strategies for HPV
16/18 positive women in primary HPV-based screening
In the study, triage model M1 required 152 colposcopies, 0 cases were
missed and 43 HSIL/CIN2+ cases were detected, in triage model M1A
95/1/42, and in triage model M2 92/1/42, respectively. The missed
HSIL/CIN2+ cases were caused by no indications for colposcopy according
to the management applied for each of the models. The full results,
including PPV values, for the 3 studied models and all the results sets
are shown in Table 2.
Tab. 2. HSIL/CIN2+ reporting rates and PPVs for detection of HSIL/CIN2+
in HPV 16/18+ cases in the compared triage models.