Abbreviations: M1, Triage model 1; M1A, Triage model 1A; M2, Triage model 2; HPV 16/18+, human papillomavirus types 16 and/or 18 positive results; NILM, negative for intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; ASC-H+, atypical squamous cells-cannot exclude HSIL or worse; DS, p16/Ki67 dual staining test; HSIL/CIN2+, histologic high-grade squamous intraepithelial lesion with a quantification of cervical intraepithelial neoplasia in grade 2 or worse; HSIL/CIN2, histologic high-grade squamous intraepithelial lesion with a quantification of cervical intraepithelial neoplasia in grade 2; PPV, positive predictive value; +, positive; −, negative; (No) numbers in parentheses, potentially missed cases, there was no indications for colposcopy for these cases.
The number of colposcopies required in triage models with incorporation of DS, M1A and M2, was around 1,6 times smaller than in model with cytology alone, M1. The analyzed models were also compared by number of colposcopies required per HSIL/CIN2+ detection, which was also approximately two times smaller in M1A and M2 than in M1 (Table 3).
Tab. 3. Number of colposcopies needed to detect HSIL/CIN2+ and number of missed HSIL/CIN2+ cases in different triage models in primary HPV-based screening.