Abbreviations: M1, Triage model 1; M1A, Triage model 1A; M2, Triage model 2; NILM, negative for intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; ASC-H+, atypical squamous cells-cannot exclude HSIL or worse; DS, p16/Ki67 dual staining test; HSIL/CIN2+, histologic high-grade squamous intraepithelial lesion with a quantification of cervical intraepithelial neoplasia in grade 2 or worse; +, positive.
Estimated selected performance of different triage strategies for HPV 16/18 positive women in primary HPV-based screening
The PPV and NPV for HSIL/CIN2+ in M1 were 28.0% and NA, respectively. The same parameters in M1A were 44.2% and 98.3%, and in M2 45.7% and 98.3%, as presented in Table 4.
Tab. 4. Clinical performance with predictive values for detection of HSIL/CIN2+ in HPV 16/18+ cases in analyzed triage models.