Abbreviations: M1, Triage model 1; M1A, Triage model 1A; M2, Triage
model 2; HPV 16/18, human papillomavirus types 16 and/or 18; NILM,
negative for intraepithelial lesion or malignancy; ASC-US, atypical
squamous cells of undetermined significance; LSIL, low-grade squamous
intraepithelial lesion; ASC-H+, atypical squamous cells-cannot exclude
HSIL or worse; DS, p16/Ki67 dual staining test; HSIL/CIN2+, histologic
high-grade squamous intraepithelial lesion with a quantification of
cervical intraepithelial neoplasia in grade 2 or worse; HSIL/CIN2,
histologic high-grade squamous intraepithelial lesion with a
quantification of cervical intraepithelial neoplasia in grade 2; PPV,
positive predictive value; NPV, negative predictive value; +, positive;
CI, confidence interval.
The difference in PPV between model with cytology triage, M1, and both
models with DS triage, M1A and M2, was statistically significant (28.3%
vs. 44.2% – p < 0.0001 and 28.3% vs. 45.7% - p <
0.0001), but there was no significant difference in PPV between M1A and
M2. The difference between NPVs in M1A and M2 was also statistically
insignificant. The detailed comparison is presented in Table 5.
Tab. 5. Comparison of predictive values for detection of HSIL/CIN2+ in
selected HPV 16/18+ cases in different triage models.