Abbreviations: M1, Triage model 1; M1A, Triage model 1A; M2, Triage
model 2; HPV 16/18+, human papillomavirus types 16 and/or 18 positive
results; NILM, negative for intraepithelial lesion or malignancy;
ASC-US, atypical squamous cells of undetermined significance; LSIL,
low-grade squamous intraepithelial lesion; ASC-H+, atypical squamous
cells-cannot exclude HSIL or worse; DS, p16/Ki67 dual staining test;
HSIL/CIN2+, histologic high-grade squamous intraepithelial lesion with a
quantification of cervical intraepithelial neoplasia in grade 2 or
worse; HSIL/CIN2, histologic high-grade squamous intraepithelial lesion
with a quantification of cervical intraepithelial neoplasia in grade 2;
PPV, positive predictive value; +, positive; −, negative; (No) numbers
in parentheses, potentially missed cases, there was no indications for
colposcopy for these cases.
The number of colposcopies required in triage models with incorporation
of DS, M1A and M2, was around 1,6 times smaller than in model with
cytology alone, M1. The analyzed models were also compared by number of
colposcopies required per HSIL/CIN2+ detection, which was also
approximately two times smaller in M1A and M2 than in M1 (Table 3).
Tab. 3. Number of colposcopies needed to detect HSIL/CIN2+ and number of
missed HSIL/CIN2+ cases in different triage models in primary HPV-based
screening.