Risk of bias and quality evaluation of individual trials
Based on the Cochrane Collaboration tool for assessing different domains
of study quality, the risk of bias was evaluated and the results are
depicted in Figure 2. Among the 17 trials, 88.23% (15/17) of the trials
demonstrated adequate random sequence generation, while one study had
unclear reporting. In addition, 82.35% (14/17) of the trials
demonstrated allocation concealment, with two trial exhibiting unclear
concealment status. 47.05% (8/17) of the trials were blinded trials.
Appropriate methods were used to handle incomplete outcome data and the
attrition and exclusion cases were also described in 88.23% (15/17) of
the trials. However, in two trials, the handling of incomplete outcome
data was not elaborately explained. In terms of selective outcome
reporting, 88.23% (15/17) of the trials demonstrated a low risk of
reporting bias (Figure 2A.B).