Risk of bias and quality evaluation of individual trials
Based on the Cochrane Collaboration tool for assessing different domains of study quality, the risk of bias was evaluated and the results are depicted in Figure 2. Among the 17 trials, 88.23% (15/17) of the trials demonstrated adequate random sequence generation, while one study had unclear reporting. In addition, 82.35% (14/17) of the trials demonstrated allocation concealment, with two trial exhibiting unclear concealment status. 47.05% (8/17) of the trials were blinded trials. Appropriate methods were used to handle incomplete outcome data and the attrition and exclusion cases were also described in 88.23% (15/17) of the trials. However, in two trials, the handling of incomplete outcome data was not elaborately explained. In terms of selective outcome reporting, 88.23% (15/17) of the trials demonstrated a low risk of reporting bias (Figure 2A.B).