Abbreviations
CKD: Chronic kidney disease; ESRD: End-stage renal disease; CVD: cardiovascular disease; ESA : erythropoiesis-stimulating agent; IV: intravenouslySC: subcutaneously; PRISMA: Preferred reporting items for systematic reviews and meta-analyses; FDA: Food and Drug Administration; rhEPO: recombinant human erythropoietin;HIF: hypoxia-inducible factor; HIF-PHI:hypoxia-inducible factor-prolyl hydroxylase inhibitor Hb:hemoglobin non- NDD: dialysis dependence; DD : dialysis dependence; AE: advance events; MACE: Major adverse cardiovascular events; RR: risk ration; CI: Confidence interval; eGFR: Estimated glomerular filtration rate;DN: Diabetic Nephropathy; BP: Blood pressure;HIF-1α:hypoxia-inducible factor 1α; DM: diabetes mellitus;eNOS: endothelial nitric oxide synthase