Data sources and search strategies
Two independent investigators conducted a comprehensive assessment followed by literature selection of relevant studies on Roxadustat for cardiovascular and renal outcome events in patients with CKD published before October 11, 2022 using the search engines PubMed, Embase database and Cochrane Central Register of Controlled Trials, with the search limited to English-language trials. Moreover, references of selected trials as well as relevant previous meta-analyses were screened to identify eligible trials that had not been identified by the database searches. All articles identified by electronic and manual selects were entered into EndNote X9. Duplicates were extracted and a database was eventually prepared for further screening.