C-176 administration post-TBI reduces cortical lesion size
The effect of C-176 on trauma-induced neuroinflammation was assessedin vivo using the CCI model of mild TBI. MRI imaging was conducted to evaluate cortical damage 24h post-TBI in mice intravenously injected 30 minutes post-TBI with a single 750nmol dose of C-176 (C-176) or a saline-vehicle control (Vehicle). Quantification of the lesion area revealed that mice treated with C-176 had significantly reduced area of damage in the cortex 24h post-TBI compared to vehicle-treated TBI mice (Fig 2).