Figure 4. C-176 significantly improves left hindlimb gait deficits 24h post-TBI.
Quantitative temporal gait parameters of mice were measured using DigiGait™ imaging and analysis software 24h after 1.5mm impact CCI surgery (TBI) and no impact (sham). No change in swing duration between treatment groups was observed (A) . Significant improvements found in (B) stance (p=0.0005) and (C) stride duration (p=0.0037), and (E) stride frequency (p=0.0041) in TBI mice treated with STING inhibitor (C-176) compared to TBI mice treated a vehicle. (D) Hindlimb stance width in C-176 treated mice significantly lower than sham (p=0.0052) and vehicle treated TBI mice (p<0.0001). Sham n = 8, TBI-vehicle n = 10, TBI-C-176 n = 13. Data is presented as mean ± SEM. Significance determined by one-way ANOVA with Tukey’s multiple comparison test. *P< 0.05, **P<0.01, ***P<0.001, ****P<0.0001