Abbreviations:
AGS = Aicardi Goutières syndrome; ARRIVE= Animal Research: Reporting ofin vivo Experiments; BBB = Blood brain barrier; CCI = Controlled cortical impact; c-di-GMP = Bis-(3’-5’)-cyclic dimeric guanosine monophosphate; cGAMP = Cyclic adenosine monophosphate guanosine monophosphate; cGAS = Cyclic guanosine monophosphate AMP synthase; Ct = Cycle threshold; CX3CR1 = C-X3-C motif chemokine receptor 1; CXCL10 = C-X-C motif chemokine ligand 10; DAMP = Danger associated molecular pattern; DAPI = 4’,6-diamino-2-phenylindole; ER = Endoplasmic reticulum; ERIS = Endoplasmic reticulum interferon stimulator; HRP = Horseradish peroxidase; IFNAR = Interferon alpha and beta receptor subunit; IKK = IκB kinase; IRF3 = Interferon regulatory factor 3; MITA = Mediator of IRF3 activation; OCT = optimal cutting temperature; PERK = Protein kinase R-like ER kinase; PFA = Paraformaldehyde; PVDF = Polyvinylidene fluoride; RARE = rapid acquisition, relaxation enhanced ; RIPA = Radioimmunoprecipitation; SAH = Subarachnoid haemorrhage; SDS = Sodium dodecyl sulphate; SLE = Systemic lupus erythematosus; STING = Stimulator of interferon genes; TBI = Traumatic brain injury; TBS = Tris-buffered saline; TBK1 = Tank binding kinase 1; TBST = Tris-buffered saline-tween; TMEM173 = Transmembrane protein 173