Conclusion and Implications:
This study demonstrates the neuroprotective activity of C-176 in ameliorating acute neuroinflammation and preventing white matter neurodegeneration post-TBI. This study highlights the therapeutic potential of small-molecule inhibitors targeting STING for the treatment of trauma induced inflammation and neuroprotective potential.
Keywords: traumatic brain injury, STING, neuroinflammation, type-I interferon, neurodegeneration