This article was previously posted to the AUTHOREA preprint server
on December 21, 2021.
Conclusions
To sum up, WD is an inheritable metabolic liver disease associated with
the accumulation of copper in the human body. Pregnancies in patients
with WD are considered high risk, not only because it poses an obvious
risk to the mother but also because the accumulating copper could affect
the unborn fetus. The proper treatment of the mother with Zinc and
Penicillamine is said to be relatively safer and has a lower risk of
congenital disability. We have tried to establish that successful
pregnancy while suffering from WD is possible through the data collected
from our case, although it does require continuous treatment and good
compliance.
References
- Huster D: Wilson
disease. Best Pract Res Clin Gastroenterol. 2010,
24:531-539. 10.1016/j.bpg.2010.07.014
- Chu NS, Hung
TP: Geographic
variations in Wilson’s disease. J Neurol Sci. 1993,
117:1-7. 10.1016/0022-510x(93)90145-o
- Lin L-J, Wang D-X, Ding N-N, Lin Y, Jin Y, Zheng
C-Q: Comprehensive
analysis on clinical features of Wilson’s disease: an experience over
28 years with 133 cases. Neurol Res. 2014,
36:157-163. 10.1179/1743132813Y.0000000262
- Ferenci
P: Diagnosis
and current therapy of Wilson’s disease. Aliment Pharmacol Ther.
2004,
19:157-165. 10.1046/j.1365-2036.2003.01813.x
- Patil M, Sheth KA, Krishnamurthy AC, Devarbhavi
H: A Review and
Current Perspective on Wilson Disease. J Clin Exp Hepatol. 2013,
3:321-336. 10.1016/j.jceh.2013.06.002
- Taly AB, Prashanth LK, Sinha
S: Wilson’s disease:
An Indian perspective. Neurol India. 2009,
57:528. 10.4103/0028-3886.57789
- Anna
Członkowska: A
study of haemolysis in Wilson’s disease. Journal of the Neurological
Sciences. 1972, Volume 16, Issue 3:Pages
303-314. 10.1016/0022-510X(72)90194-3
- Attri S, Sharma N, Jahagirdar S, Thapa BR, Prasad
R: Erythrocyte
Metabolism and Antioxidant Status of Patients with Wilson Disease with
Hemolytic Anemia. Pediatr Res. 2006594,
1:593-597. 10.1203/01.pdr.0000203098.77573.39
- Ferenci P, Caca K, Loudianos G, et
al.: Diagnosis
and phenotypic classification of Wilson disease1. Liver Int. 2003,
23:139-142. 10.1034/j.1600-0676.2003.00824.x
- Saito T: Presenting
symptoms and natural history of Wilson disease. Eur J Pediatr. 1987,
146:261-265. 10.1007/BF00716470
- Frommer DJ: Urinary copper
excretion and hepatic copper concentrations in liver disease.
Digestion. 1981,
21:169-178. 10.1159/000198559
- Perman JA, Werlin SL, Grand RJ, Watkins
JB: Laboratory
measures of copper metabolism in the differentiation of chronic active
hepatitis and Wilson disease in children. J Pediatr. 1979,
94:564-568. 10.1016/S0022-3476(79)80011-6
- Roberts EA, Schilsky
ML: Diagnosis and
treatment of Wilson disease: An update. Hepatology. 2008,
47:2089-2111. 10.1002/hep.22261
- Tietz Textbook
of: Clinical
Chemistry and Molecular DiagnosticsAccessed September 18. 2020.
- Fukuda K, Ishii A, Matsue Y, Funaki K, Hoshiai H, Maeda
S: Pregnancy and
delivery in penicillamine treated patients with Wilson’s disease.
Tohoku J Exp Med. 1977,
123:279-285. 10.1620/tjem.123.279
- Sinha S, Taly AB, Prashanth LK, Arunodaya GR, Swamy
HS: Successful
pregnancies and abortions in symptomatic and asymptomatic Wilson’s
disease. J Neurol Sci. 2004,
217:37-40. 10.1016/j.jns.2003.08.007
- Malik A, Khawaja A, Sheikh
L: Wilson’s disease
in pregnancy: case series and review of literature. BMC Res Notes.
2013,
6:421. 10.1186/1756-0500-6-421
- Mustafa MS, Shamina
AH: Five
successful deliveries following 9 consecutive spontaneous abortions in
a patient with Wilson disease. Aust N Z J Obstet Gynaecol. 1998,
38:312-314. 10.1111/j.1479-828x.1998.tb03073.x
- Morimoto I, Ninomiya H, Komatsu K, Satho
M: Pregnancy
and Penicillamine Treatment in a Patient with Wilson’s Disease. Jpn J
Med. 1986,
25:59-62. 10.2169/internalmedicine1962.25.59
- Brewer GJ, Johnson VD, Dick RD, Hedera P, Fink JK, Kluin
KJ: Treatment of
Wilson’s disease with zinc. XVII: treatment during pregnancy. Hepatol
Baltim Md. 2000,
31:364-370. 10.1002/hep.510310216