5. Conclusions
Several studies have been performed towards understanding the aggressive
behavior of high-grade gliomas. However, the significance of
oligosaccharyltransferase mediated tumor progression and invasiveness is
still unclear. High grade gliomas are extremely mesenchymal in nature
which further contributes towards the aggressive nature of gliomas. This
mesenchymal transition is accompanied by the over expression of several
glycoproteins and in turn responsible for extra cellular matrix
remodelling. Numerous studies have suggested that OST-mediated
glycosylation contributes to the development of various malignancies. In
the current study, we have found a connecting link between the over
expression of OST and tumor invasiveness of high-grade gliomas. Since
the study involves small set of samples particularly for the LGG cohort,
therefore the findings should be validated on the large cohort of
samples. In addition, glycoprotein enriched samples could provide better
insight in the role of OST mediated glycosylation. This study identifies
the key proteins involved in ECM remodelling and in turn responsible for
EMT transition, these can be used as novel clinical markers or
therapeutic targets for tailored management of high-grade gliomas.
Finally, the study reveals the importance of oligosaccharyltransferase
in aggressive behaviour of high-grade gliomas, highlighting OST as a
potential target for cancer therapy.