2.5 Gene set enrichment analysis and protein-protein interaction analysis
The identified protein list was used for pre-ranked Gene set enrichment analysis (GSEA) using Hallmark (16) and KEGG database (17). The number of permutations was set to 1000. Further, Cytoscape (Version 3.9.1) was used to visualize the enriched pathways (18). For protein-protein interaction analysis, significant protein list was used as input for STRING (Version 11.5), keeping the interaction score to 0.4.