5. Conclusions
Several studies have been performed towards understanding the aggressive behavior of high-grade gliomas. However, the significance of oligosaccharyltransferase mediated tumor progression and invasiveness is still unclear. High grade gliomas are extremely mesenchymal in nature which further contributes towards the aggressive nature of gliomas. This mesenchymal transition is accompanied by the over expression of several glycoproteins and in turn responsible for extra cellular matrix remodelling. Numerous studies have suggested that OST-mediated glycosylation contributes to the development of various malignancies. In the current study, we have found a connecting link between the over expression of OST and tumor invasiveness of high-grade gliomas. Since the study involves small set of samples particularly for the LGG cohort, therefore the findings should be validated on the large cohort of samples. In addition, glycoprotein enriched samples could provide better insight in the role of OST mediated glycosylation. This study identifies the key proteins involved in ECM remodelling and in turn responsible for EMT transition, these can be used as novel clinical markers or therapeutic targets for tailored management of high-grade gliomas. Finally, the study reveals the importance of oligosaccharyltransferase in aggressive behaviour of high-grade gliomas, highlighting OST as a potential target for cancer therapy.