Limited antibody response after BA.4/5 adapted booster vaccination in rheumatic patients receiving anti-TNF therapy: results of a case series

Ulf Martin Geisen^1*, Mathias Voß^2*, Ruben Rose^2*, Franziska Neumann³, Carina Bäumler³, Sina Müller³, Lea Paltzow³, Christina Martínez Christophersen³, Merle Münier³, Elena Hildebrand¹, Paula Hoff⁴, Ann Carolin Longardt⁵, Thomas Lorentz³, Jan Henrik Schirmer¹, Melike Sümbül⁶, Florian Tran^7,8, Dennis Berner¹, Helmut Fickenscher², Sascha Gerdes⁶, Stefan Schreiber^7,8, Andi Krumbholz^2,3‡, Bimba Franziska Hoyer^1‡

1 Medical Department I, Rheumatology, and Clinical Immunology, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany

2 Institute for Infection Medicine, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

3 Labor Dr. Krause und Kollegen MVZ GmbH, Kiel, Germany

4 Department of Rheumatology, Endokrinologikum-Gruppe, Berlin, Germany

5 Department of Pediatrics, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany

6 Department for Dermatology, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany

7 Institute of Clinical Molecular Biology, Christian-Albrecht University of Kiel, Kiel, Germany

8 Department for Internal Medicine I, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein Campus Kiel

* ‡These authors contributed equally

Corresponding Author: Bimba Franziska Hoyer

Medical Department I, Rheumatology and Clinial Immunology,

University Medical Center Schleswig-Holstein

Arnold-Heller-Str. 3

24105 Kiel

Email: bfhoyer@rheuma.uni-kiel.de

Phone: +49 431 500 22203