A 11-year-old female patient with tuberous sclerosis presented with retinal hamartomas at different stages of evolution in the optical coherence tomography with Sweep Source technology (OCT-SS). The right eye presented with three lesions spectra. Lesion 1, at an earlier stage, maximum thickness (MT) of 336 μm, preserved inner nuclear and inner plexiform layers and disorganization of the ganglion cell layer. Lesion 2, MT of 438 μm and disorganization of the ganglion cell, inner nuclear and inner plexiform layers, but outer plexiform layer apparently preserved. Lesion 3, a hyperreflective dome-shaped proliferation with posterior shadow, MT of 1478 μm, presented “moth-eaten” empty optical spaces, with an apparent complete rupture of the retinal anatomy. In the left eye, the lesion had a MT of 342 μm, preserved the retinal anatomy, located at the level of the retinal nerve fiber layer, and identifiable ganglion cell layer.