|
Knock-out |
Over-expression |
|
|
|
|
C. glutamicum
|
WT
ldhA
ldhA+pyc
|
-
-
-
|
36 g L-1 glucose
|
4.4 g L-1 (3 h)
5.0 g L-1 (3 h)
2.4 g L-1 (3 h)
|
1.47
1.67
0.80
|
[6]
|
C. glutamicum |
- |
- |
337.5 g L-1 glucose |
93.6 g L-1 (fed-batch, 65 h) |
1.44 |
[48] |
C. glutamicum |
ldhA |
pyc |
288 g
L-1 glucose |
146 g L-1 (fed-batch,
46 h) |
3.20 |
[5] |
C. glutamicum
|
ldhA
|
xylA+xylB+ gapA+pntAB
|
40 g L-1 glucose
|
23-26 g L-1 (18 h)
|
1.28
–1.44
|
[49]
|
C. glutamicum
|
ldhA
|
xylA+xylB+gapA
|
66.1 g L-1 glucose
139.1 g L-1 glucose
|
43.3 g L-1 (8 h)
113 g L-1 (fed-batch, 48 h)
|
5.41
2.35
|
[10]
|
C. glutamicum |
ldhA |
xylA+xylB+
gapA
|
Corn cob hydrolysate (55 g L-1 xylose, 4
g L-1 glucose) |
40.8 g L-1 (48 h) |
0.85 |
[29] |
C. glutamicum
|
ldhA+pqo+cat+
ackA
|
pyc+ppc+gltA+
sucE+aceA+
aceB
|
20 g L-1 glucose
150 g L-1 glucose
|
18.7 g L-1 (12 h)
109 g L-1 (fed-batch, 100 h)
|
1.56
1.09
|
[8]
|
C. glutamicum |
ldhA+pta+ack +pqo+cat |
pyc+fdh+gapA |
20 g L-1 glucose + 15 g
L-1 formate |
14.17 g L-1 (5 h) |
2.83 |
[50] |
C. glutamicum
|
ldhA+pta:ackA
+actA+poxB+pck+ptsG
|
pyc+ppc+pckG+whiB4
|
40 g L-1 glucose
220 g L-1 glucose
|
9.98 g L-1 (24 h)
152.2 g L-1 (fed-batch, 160 h)
|
0.41
0.95
|
[51]
|
E. coli
|
-
-
-
|
-
pyc
pyc
|
20 g L-1 glucose
20 g L-1 glucose
Cocos nucifera water
|
1.08 g L-1 (48 h)
1.82 g L-1 (48 h)
11.75 g L-1 (7.5 h)
|
0.02
0.03
1.13
|
[52]
|
E. coli |
ldhA+ackA+ dhE+pflB+mgsA+ poxB |
- |
100 g
L-1 glucose |
43.0 g L-1 (72 h) |
0.59 |
[53] |
E. coli |
ptsG+pflB+ldhA |
- |
5% detoxified softwood
dilute sulfuric acid hydrolysates |
39.5 g L-1 (48 h) |
0.82 |
[54] |
A. succinogenes |
- |
- |
80 g L-1 DDAP
hydrolysate of corn stover |
42.6 g L-1 (54 h) |
0.78 |
[55] |
A. succinogenes
|
WT
ackA+pflB
|
-
pck+mdh+fum
|
60 g L-1 mimicking the DDAP hydrolysate (6.5 g
L-1 glucose, 44 g L-1 xylose, 3.5 g
L-1 galactose, 6.5 g L-1 arabinose)
|
25.0 g L-1 (72 h)
13.5 g L-1 (72 h)
|
0.35
0.18
|
[4]
|
A. succinogenes |
- |
- |
58 g L-1 corn straw
hydrolysate (Dilute-alkali pretreatment) |
45.5 g L-1
(48 h) |
0.95 |
[56] |
A. succinogenes |
- |
- |
Napier grass hydrolysate (22.5 g
L-1 glucose, 10.6 g L-1 xylose) |
17.5 g L-1 (22 h) |
0.79 |
[57] |
M. succiniciproducens
|
-
|
-
|
Oak wood hydrolysate (22.82 g L-1 glucose, 7.4 g
L-1 xylose)
|
11.78 g L-1 (10 h)
7.98 g L-1 (Continuous fermentation, 2.5 h)
|
1.17
3.19
|
[2]
|
Y. lipolytica
|
Ylsdh5
|
-
|
200 g L-1 glycerol
625 g L-1 glycerol
|
43 g L-1 (120 h)
160 g L-1 (fed-batch, 400 h)
|
0.36
0.40
|
[3]
|
C. glutamicm
|
LdhA
LdhA
LdhA
|
-
sucE
sucE
|
4% pine hydrolysate
4% pine hydrolysate
4% + 30.7 g L-1 pine hydrolysate
|
14.82 g L-1 (6 h)
17.70 g L-1 (6 h)
39.7 g L-1 (fed-batch, 48 h)
|
2.47
2.95
0.83
|
This study
|