Clinical diagnosis criteria
Patients with the following symptoms were defined as cases of HFMD:
fever; papules and herpes on the mucous membranes of the hands, feet, or
mouth; rash on the buttocks or knees with inflammatory flushing around
the rash, and blisters with a small amount of fluid. Severe cases of
HFMD were defined as the presence of additional neurologic, cardiogenic,
or pulmonary disease.