Figure 4. A. Alignment of H8-L -H9 sequences
from 13 bacterial GluRSs with known crystal structures. Each sequence is
annotated with pdb ID, bacterial species (three-letter KEGG code), and
structure (“>>t ” and
“t<< ” denotes towards and away from tRNA,
respectively). The sequence logo on the top represents first four
sequences, for which inter-residue hydrophobic/aromatic (black solid
lines) and H-bond (red broken line) interactions are shown (see panel B
for details). B. Structural superposition of H8-L -H9
motifs in first four proteobacterial GluRSs in panel A. All side-chains
that participate in inter-residue interactions shown in panel A are
shown as stick model (residue numberings correspond toEco -GluRS).