Conclusion
To the best of our knowledge, this is the first case of hereditary hemorrhagic telangiectasia (HHT) to be reported from Ethiopia. High degree of suspicion and early diagnosis of HHT is essential to start preventive screening and surveillance and intervene timely because of its fatal complications. Recurrent massive epistaxis and gastrointestinal hemorrhage leads to severe anemia and heart failure. In resource limited settings, selective cauterization of telangiectasia will help to control bleeding, although it does not avoid recurrent bleeding.