CONCLUSION
Maternal COVID-19 seems to have both morphological and functional effects on the fetal, neonatal and infant heart. To date, this is the first case-control, longitudinal study evaluating the comprehensive effect of maternal COVID-19 disease on cardiac functions of the fetuses and infants.
AUTHOR CONTRIBUTIONS YÖŞ prepared and wrote the original draft, analysis, interpretation and contributed to data collection. BS contributed to data collection, ŞGA contributed to data collection and literatüre search. AEKG performed the literature search and was responsible for conceptualization, methodology. AT performed the project development. İİÇ and DS were responsible for visualization, and reviewing and editing.
ACKNOWLEDGMENT Special thanks to all healthcare staff who works very hard to improve the health standards of the pregnant women, newborns and children during pandemic period.
CONFLICT OF INTEREST The authors declare no conflict of interest.
FUNDING SOURCES None
DISCLOSURES None
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
REFERENCES :
[1] World Health Organization (WHO). Coronavirus disease (COVID‐19) overview webpage [Online]/COVID-19 Dashboard. Available from: https://covid19.who. int/ [Accessed 25 May 2023]
[2] Sahin D, Tanacan A, Erol SA, et al. Updated experience of a tertiary pandemic center on 533 pregnant women with COVID-19 infection: A prospective cohort study from Turkey. Int J Gynaecol Obstet.2021 Mar;152(3):328-334.
[3] Allotey J, Stallings E, Bonet M, et al. for PregCOV-19 Living Systematic Review Consortium. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020 Sep 1;370:m3320.
[4] DeBolt CA, Bianco A, Limaye MA, et al. Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controls. Am J Obstet Gynecol . 2021 May;224(5):510.e1-510.e12.
[5] Di Girolamo R, Khalil A, Alameddine S, et al. Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2021 Nov;3(6):100468.
[6] Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Reviriego AA. Cardiovascular impact of COVID-19 with a focus on children: A systematic review. World J Clin Cases. 2020 Nov 6;8(21):5250-5283.
[7] Pawar R, Gavade V, Patil N, et al. Neonatal Multisystem Inflammatory Syndrome (MIS-N) Associated with Prenatal Maternal SARS-CoV-2: A Case Series. Children (Basel). 2021 Jul 2;8(7):572.
[8] Cantarutti N, Battista V, Stagnaro N, et al. Long-Term Cardiovascular Outcome in Children with MIS-C Linked to SARS-CoV-2 Infection-An Italian Multicenter Experience. Biology (Basel).2022 Oct 8;11(10):1474.
[9] Arslan SY, Bal ZS, Bayraktaroglu S, Ozenen GG, et al. Cardiac Assessment in Children with MIS-C: Late Magnetic Resonance Imaging Features. Pediatr Cardiol. 2023 Jan;44(1):44-53.
[10] Şahin D, Tanaçan A, Webster SN, Moraloğlu Tekin Ö. Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turk J Med Sci. 2021 Dec 17;51(SI-1):3312-3326.
[11] World Health Organization. Living Guidance for clinical management of COVID-19. Published:January 2023. WHO/2019-nCoV/clinical/2021.2
[12] Lai WW, Geva T, Shirali GS et al. Task Force of the Pediatric Council of the American Society of Echocardiography; Pediatric Council of the American Society of Echocardiography. Guidelines and standards for performance of a pediatric echocardiogram: a report from the Task Force of the Pediatric Council of the American Society of Echocardiography. J Am Soc Echocardiogr. 2006 Dec;19(12):1413-30.
[13] Lopez L, Colan SD, Frommelt PC et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr. 2010 May;23(5):465-95; quiz 576-7.
[14] Altın H, Karaarslan S, Karataş Z, Alp H, Şap F, Baysal T. Evaluation of cardiac functions in term small for gestational age newborns with mild growth retardation: a serial conventional and tissue Doppler imaging echocardiographic study. Early Hum Dev. 2012 Sep;88(9):757-64.
[15] McMurray JC, May JW, Cunningham MW, Jones OY. Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis-A Critical Review of Its Pathogenesis and Treatment.Front Pediatr. 2020 Dec 16;8:626182.
[16] Sawalha K, Abozenah M, Kadado AJ et al. Systematic Review of COVID-19 Related Myocarditis: Insights on Management and Outcome.Cardiovasc Revasc Med. 2021 Feb;23:107-113.
[17] Gee S, Chandiramani M, Seow J, et al. The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate. Nat Immunol. 2021 Dec;22(12):1490-1502.
[18] Shaiba LA, More K, Hadid A et al. Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review. Neonatology.2022;119(4):405-417.
[19] De Rose DU, Pugnaloni F, Calì M et al. Multisystem Inflammatory Syndrome in Neonates Born to Mothers with SARS-CoV-2 Infection (MIS-N) and in Neonates and Infants Younger Than 6 Months with Acquired COVID-19 (MIS-C): A Systematic Review. Viruses. 2022 Apr 2;14(4):750.
[20] Rizzo G, Mappa I, Pietrolucci ME et al. Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study. J Perinat Med. 2022 Jan 21;50(4):398-403.
[21] Ayhan S, Turgut E, Ozden Tokalioglu E et al. Post-COVID-19 fetal cardiac evaluation in moderate infection group of pregnant women.J Clin Ultrasound. 2022 Jun;50(5):630-635.
[22] Hatém MA, Zielinsky P, Hatém DM et al. Assessment of diastolic ventricular function in fetuses of diabetic mothers using tissue Doppler. Cardiol Young. 2008 Jun;18(3):297-302.
[23] Patey O, Carvalho JS, Thilaganathan B. Perinatal changes in fetal cardiac geometry and function in diabetic pregnancy at term.Ultrasound Obstet Gynecol. 2019 Nov;54(5):634-642.
[24] Schoenmakers S, Snijder P, Verdijk RM, Kuiken T, Kamphuis SSM, Koopman LP, Krasemann TB, Rousian M, Broekhuizen M, Steegers EAP, Koopmans MPG, Fraaij PLA, Reiss IKM. Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman.J Pediatric Infect Dis Soc. 2021 May 28;10(5):556-561.