References
Abel, E.D., Peroni, O., Kim, J.K., Kim, Y.B., Boss, O., Hadro, E., Minnemann, T., Shulman, G.I. and Kahn, B.B. (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.Nature 409 , 729-733.
Adolph, S., Schedlbauer, C., Blaue, D., Schöniger, A., Gittel, C., Brehm, W., Fuhrmann, H. and Vervuert, I. (2019) Lipid classes in adipose tissues and liver differ between Shetland ponies and Warmblood horses.PLoS ONE 14 .
Ameer, F., Scandiuzzi, L., Hasnain, S., Kalbacher, H. and Zaidi, N. (2014) De novo lipogenesis in health and disease. Metabolism63 , 895-902.
Banerjee, R.R. and Lazar, M.A. (2003) Resistin: molecular history and prognosis. J Mol Med (Berl) 81 , 218-226.
Banerjee, R.R., Rangwala, S.M., Shapiro, J.S., Rich, A.S., Rhoades, B., Qi, Y., Wang, J., Rajala, M.W., Pocai, A., Scherer, P.E., Steppan, C.M., Ahima, R.S., Obici, S., Rossetti, L. and Lazar, M.A. (2004) Regulation of fasted blood glucose by resistin. Science 303 , 1195-1198.
Basinska, K., Marycz, K., Śieszek, A. and Nicpoń, J. (2015) The production and distribution of IL-6 and TNF-a in subcutaneous adipose tissue and their correlation with serum concentrations in Welsh ponies with equine metabolic syndrome. J Vet Sci 16 , 113-120.
Bergman, R.N., Kim, S.P., Catalano, K.J., Hsu, I.R., Chiu, J.D., Kabir, M., Hucking, K. and Ader, M. (2006) Why visceral fat is bad: mechanisms of the metabolic syndrome. Obesity (Silver Spring) 14 Suppl 1 , 16s-19s.
Blüher, M. (2016) Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance? Clin Sci (Lond) 130 , 1603-1614.
Booth, A., Magnuson, A., Foster, M., (2014) Detrimental and protective fat: body fat distribution and its relation to metabolic disease. Hormone molecular biology and clinical investigation 17 , 13-27.
Bruynsteen, L., Erkens, T., Peelman, L.J., Ducatelle, R., Janssens, G.P.J., Harris, P.A. and Hesta, M. (2013) Expression of inflammation-related genes is associated with adipose tissue location in horses. BMC Veterinary Research 9 .
Buff, P.R., Dodds, A.C., Morrison, C.D., Whitley, N.C., McFadin, E.L., Daniel, J.A., Djiane, J. and Keisler, D.H. (2002) Leptin in horses: Tissue localization and relationship between peripheral concentrations of leptin and body condition. J Anim Sci 80 , 2942-2948.
Bukowska, J., Szóstek-Mioduchowska, A.Z., Kopcewicz, M., Walendzik, K., Machcińska, S. and Gawrońska-Kozak, B. (2021) Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science. Stem Cell Rev Rep 17 , 719-738.
Burns, T.A., Geor, R.J., Mudge, M.C., McCutcheon, L.J., Hinchcliff, K.W. and Belknap, J.K. (2010) Proinflammatory cytokine and chemokine gene expression profiles in subcutaneous and visceral adipose tissue depots of insulin-resistant and insulin-sensitive light breed horses.Journal of Veterinary Internal Medicine 24 , 932-939.
Dugdale, A.H.A., Curtis, G.C., Harris, P.A. and Argo, C.M. (2011) Assessment of body fat in the pony: Part I. Relationships between the anatomical distribution of adipose tissue, body composition and body condition. Equine Vet J 43 , 552-561.
Dugdale, A.H., Grove-White, D., Curtis, G.C., Harris, P.A., Argo, C.M., (2012) Body condition scoring as a predictor of body fat in horses and ponies. The Veterinary Journal 194 , 173-178.
Garg, A., (2004) Acquired and inherited lipodystrophies. New England Journal of Medicine 350 , 1220-1234.
Duncan, R.E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E. and Sul, H.S. (2007) Regulation of lipolysis in adipocytes. Annu Rev Nutr27 , 79-101.
Fain, J.N., Madan, A.K., Hiler, M.L., Cheema, P. and Bahouth, S.W. (2004) Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology145 , 2273-2282.
Fang, H., Judd, R.L., (2011) Adiponectin regulation and function. Comprehensive Physiology 8 , 1031-1063.
Fuentes-Romero, B., Muñoz-Prieto, A., Cerón, J.J., Martín-Cuervo, M., Iglesias-García, M., Aguilera-Tejero, E. and Díez-Castro, E. (2021) Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders. Animals (Basel) 12 .
Garg, A. (2004) Acquired and inherited lipodystrophies. N Engl J Med 350 , 1220-1234.
Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., Smith, U., (2018) Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity. Physiological reviews 98 , 1911-1941.
Ibrahim, M.M., (2010) Subcutaneous and visceral adipose tissue: structural and functional differences. Obesity reviews 11 , 11-18.
Imi, Y., Ogawa, W. and Hosooka, T. (2023) Insulin resistance in adipose tissue and metabolic diseases. Diabetol Int 14 , 119-124.
Jayathilake, W., Furr, M., Risco, C. and Lacombe, V.A. (2022) Equine insulin dysregulation causes tissue specific alterations of proinflammatory cytokines and acute phase proteins in a NF-kB independent manner. Vet Immunol Immunopathol 253 , 110500.
Kahn, B.B. and Flier, J.S. (2000) Obesity and insulin resistance.Journal of Clinical Investigation 106 , 473-481.
Kahn, S.E., Hull, R.L. and Utzschneider, K.M. (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature444 , 840-846.
Kearns, C.F., McKeever, K.H., Roegner, V., Brady, S.M., Malinowski, K., (2006) Adiponectin and leptin are related to fat mass in horses. Vet J172 , 460-465.
Kiranmayi, V.S., Bhargav, K.M., (2019) Brown Adipose Tissue in Adult Humans: A Mini Review. Journal of Clinical and Scientific Research8 , 24-28.
Kwon, H., Kim, D. and Kim, J.S. (2017) Body Fat Distribution and the Risk of Incident Metabolic Syndrome: A Longitudinal Cohort Study.Sci Rep 7 , 10955.
Liu, X., Zhang, Z., Song, Y., Xie, H. and Dong, M. (2022) An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications. Front Endocrinol (Lausanne)13 , 1065263.
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G.A., Beguinot, F. and Miele, C. (2019) Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. Int J Mol Sci 20 .
Marycz, K., Kornicka, K., Grzesiak, J., Śmieszek, A. and Szłapka, J. (2016) Macroautophagy and Selective Mitophagy Ameliorate Chondrogenic Differentiation Potential in Adipose Stem Cells of Equine Metabolic Syndrome: New Findings in the Field of Progenitor Cells Differentiation.Oxid Med Cell Longev 2016 , 3718468.
Morgan, R.A., Beck, K.R., Nixon, M., Homer, N.Z.M., Crawford, A.A., Melchers, D., Houtman, R., Meijer, O.C., Stomby, A., Anderson, A.J., Upreti, R., Stimson, R.H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E.E., Björkegren, J.L.M., Andrew, R., Kenyon, C.J., Hadoke, P.W.F., Odermatt, A., Keen, J.A. and Walker, B.R. (2017) Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.Scientific Reports 7 .
Morgan, R.A., Keen, J.A., Homer, N., Nixon, M., McKinnon-Garvin, A.M., Moses-Williams, J.A., Davis, S.R., Hadoke, P.W.F. and Walker, B.R. (2018) Dysregulation of cortisol metabolism in equine pituitary pars intermedia dysfunction. Endocrinology 159 , 3791-3800.
Reynolds, A., Keen, J.A., Fordham, T. and Morgan, R.A. (2019) Adipose tissue dysfunction in obese horses with equine metabolic syndrome.Equine Vet J 51 , 760-766.
Ruan, H., Miles, P.D., Ladd, C.M., Ross, K., Golub, T.R., Olefsky, J.M. and Lodish, H.F. (2002) Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes 51 , 3176-3188.
Santillana, N., Astudillo-Guerrero, C., D’Espessailles, A. and Cruz, G. (2023) White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements. Nutrients 15 .
Staub, C., Venturi, E., Cirot, M., Léonard, L., Barrière, P., Blard, T., Gaudé, Y., Gascogne, T., Yvon, J.M., Lecompte, F., Ramé, C., Reigner, F. and Dupont, J. (2019) Ultrasonographic measures of body fatness and their relationship with plasma levels and adipose tissue expression of four adipokines in Welsh pony mares. Domest Anim Endocrinol69 , 75-83.
Suagee, J.K., Corl, B.A., Crisman, M.V., Wearn, J.G., McCutcheon, L.J. and Geor, R.J. (2010) De novo fatty acid synthesis and NADPH generation in equine adipose and liver tissue. Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 155 , 322-326.
Thomas, E.L., Parkinson, J.R., Frost, G.S., Goldstone, A.P., Doré, C.J., McCarthy, J.P., Collins, A.L., Fitzpatrick, J.A., Durighel, G., Taylor-Robinson, S.D. and Bell, J.D. (2012) The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity (Silver Spring) 20 , 76-87.
Wallis, N., Raffan, E., (2020) The genetic basis of obesity and related metabolic diseases in humans and companion animals. Genes 11 , 1378.
Warnken, T., Brehm, R., Feige, K. and Huber, K. (2017) Insulin signaling in various equine tissues under basal conditions and acute stimulation by intravenously injected insulin. Domestic Animal Endocrinology61 , 17-26.
Yadav, A., Kataria, M.A. and Saini, V. (2013) Role of leptin and adiponectin in insulin resistance. Clin Chim Acta 417 , 80-84.