SULT1A1 activity of human breast cancer sample
Sulfotransferase also utilizes PAPS as sulfonate donor to catalyze the
sulfate conjugation of a wide variety of acceptor molecules bearing a
hydroxyl or an amine group including estrogen. To find whether E2 is
controlled by other E2 regulating enzymes such as SULT1A1, we did
SULT1A1 activity assay. Interestingly we found no difference in the
SULT1A1 activity between tumor and their surrounding tissue (Fig-1b).
Thus, there is no SULT1A1 interference in the final outcome of E2.