PK parameter |
Observed |
Simulated |
AAFE |
RAL |
|
|
|
2nd trimester‡a
|
|
|
|
C12 (ng/ml) |
62.1 |
34 |
1.81 |
Cmax (ng/ml) |
2250 |
1386 |
1.62 |
AUC0-12 (ng.h/ml) |
6600 |
6622 |
1.00 |
3rd trimester‡a
|
|
|
|
C12 (ng/ml) |
64 |
36 |
1.78 |
Cmax (ng/ml) |
1770 |
1458 |
1.21 |
AUC0-12 (ng.h/ml) |
5400 |
7084 |
1.31 |
3rd trimester^b
|
|
|
|
C12 (ng/ml) |
77 |
42 |
1.84 |
Cmax (ng/ml) |
1430 |
1515 |
1.06 |
AUC0-inf (ng.h/ml) |
5000 |
7366 |
1.47 |
RPV |
|
|
|
2nd trimester#c
|
|
|
|
Cmin (ng/ml) |
54.3 |
30.2 |
1.80 |
Cmax (ng/ml) |
121 |
166 |
1.37 |
AUC0-24 (ng.h/ml) |
1792 |
2226 |
1.24 |
3rd trimester#c
|
|
|
|
Cmin (ng/ml) |
52.9 |
36.5 |
1.45 |
Cmax (ng/ml) |
123 |
177 |
1.44 |
AUC0-24 (ng.h/ml) |
1762 |
2456 |
1.39 |
3rd trimester^d
|
|
|
|
Cmin (ng/ml) |
50 |
33 |
1.50 |
Cmax (ng/ml) |
110 |
170 |
1.57 |
AUC0-24 (ng.h/ml) |
1710 |
2400 |
1.39 |