CAB – cabotegravir, RAL – raltegravir, RPV - rilpivirine, pKa - acid dissociation constant, R - blood-to-plasma drug ratio, Log P_o:w - partition coefficient between octanol and water, f_up - fraction of drug unbound in plasma, HBD - number of hydrogen bond donors, PSA - polar surface area, P_app- apparent permeability coefficient, Cl_int - intrinsic clearance, CYP - cytochrome P450, UGT - uridine diphosphate-glucuronosyltransferase.

^aµL/min/10⁶ hepatocytes.

^bvalue fitted in the model using available clinical PK data.

Table 2: Key pregnancy-induced anatomical, physiological, and metabolic changes implemented in the pregnancy model