Data presented as geometric mean values.# Clinical data observed by Spreen et
al 2014 [34]. AAFE – absolute average fold error;
Cτ – plasma concentration at the end of the dosing
interval, Cmax – maximum plasma concentration,
AUC0-τ – area under the plasma concentration time curve
within the dosing interval, IM – intramuscular.
Table 5: Qualification of pregnancy PBPK model for oral PK of RAL and
RPV in pregnant women (simulated vs observed)