Drug parameter CAB RAL RPV
Molecular weight 405 444 366
pKa 10.04 [40] 6.67 [32] 3.26 [40]
R 0.441 [40] 0.6 [32] 0.67 [40]
Log Po:w 1.04 [40] 0.58 [32] 4.32 [40]
fup 0.007 [40] 0.17 [32] 0.003 [40]
HBD 2 [40]
PSA 99.2 [40]
Caco-2 Papp (cm/s) 6.6 x 10-6 [32] 12 x 10-6 [40]
CYP3A4 CLint (µL/min/pmol) 2.04 [40]
UGT1A1 CLint (µL/min/mg) 4.5 [40] 12.4a [32]
UGT1A9 CLint (µL/min/mg) 2.2 [40]
IM drug release rateb (h-1) 3.406 x 10-4 4.5 x 10-4