PK parameters between week 9-12 of drug administration; #PK parameters between week 5-12 of drug administration; Ctrough – plasma concentration at the end of the dosing interval, Cmax – maximum plasma concentration within the dosing interval, AUC0-inf – area under the plasma plasma concentration time curve till infinity,AUC0-672 – area under the plasma plasma concentration time curve within the last dosing interval period of 1 month (672 hrs), AUC0-1344 – area under the plasma concentration time curve within the last dosing interval period of 2 months (1344 hrs), SD – standard deviation.