2.5 Control dataset
The global comparison of the structure network was performed earlier on
a dataset of single chain single domain proteins to determine their
structure variability. There, all pairs of available multiple conformers
of the same protein are compared to determine the network dissimilarity
(NDS) and structure deviation (RMSD) scores. In this work, the data from
the previous analysis has been used as a control to understand the
significance of the variability obtained upon transient association. The
two-sample Kolmogorov-Smirnov test (KS test) is performed to test the
significance of the data obtained in the working dataset as compared to
the corresponding scores of the control dataset.