FIGURE LEGENDS
Figure 1 TDP-43 and main partners. While mostly nuclear, TDP-43 performs several vital functions both in the nucleus and in the cytoplasm of cells, interacting with distinct partners. The main functions are 1) RNA transcription, 2) miRNA processing, 3) mRNA splicing, 4) lncRNA processing, 5) stress granule formation, 6) nuclear-cytoplasmic shuttling, 7) mRNA transport and 8) translation.
Figure 2 Structure and domains of TDP-43. A) TDP-43 is composed by a well-structured N-terminal region, containing a nuclear localization sequence (NLS) and two RNA recognition motifs (RRM1 and RRM2). The low complexity domain at the C-terminal part contains a glutamine/asparagine-rich region (Q/N). In the upper part of the image, the most prominent pathogenic mutations are annotated. In the lower part of the image the post-translational modifications that are referred to in the text are color-coded. Blue, yellow and red stand for ubiquitination, acetylation and phosphorylation, respectively. Residues with more than one annotated PTM are marked with two colors. B) Structural model of TDP-43 provided by AlphaFold [191]. Protein domains are annotated, including the disordered C-terminal tail.
Table 1.- List of TDP-43 protein interactors detected in at least 2 independent studies, sorted by function in RNA processing.