Main Findings
Previous studies have shown a
link between TAFI and RSA, but there has been controversy. These studies
tend to focus on the potential effects of TAFI on RSA in terms of
coagulation and fibrinolysis. And the presence of ATA in the body can
lead to inflammatory reactions, which has caught our attention.
Therefore, we conducted a retrospective case-control study to explore
the effect of TAFI levels on RSA under different conditions of ATA, and
found that when the plasma TAFI level is below the normal range of TAFI,
there is a high risk of RSA in the Anti-TPO positive, Anti-TPO negative,
and Anti-TG positive populations. There is a dose-response relationship
between plasma TAFI levels and the risk of RSA, which is significantly
associated.