Multifactorial logistic analysis of independent risk factors for RSA
The factors independently associated with RSA in different groups are shown in Table 3. In the overall population, TAFI, DD, and RDW-CV variables were shown to be protective factors, all other variables were considered risk factors. The regression analysis results showed that the β-coefficient of plasma TAFI level was -0.04 [odds ratio (OR) 0.961; 95% CI, 0.936-0.987; P = 0.004].
In the Anti-TPO positive and Anti-TG positive populations, relatively few factors were independently associated with RSA. In the Anti-TPO positive group, TAFI (OR, 0.943; 95% CI, 0.896-0.992; P = 0.025], LYMPH (OR. 1.034; 95% CI, 1.003-1.066; P =0.03), and LY30 (OR, 0.162; 95% CI, 0.035-0.738; P=0.019) were independent predictors of RSA. In the Anti-TG positive group, TAFI (OR, 0.937; 95% CI, 0.884-0.992; P = 0.027), age (OR, 1.133; 95% CI, 1.057-1.215; P < 0.001), Fib (OR, 0.593; 95% CI, 0.393-0.893; P = 0.012). FT3(OR, 2.205;95% CI, 1.307-3.722; P=0.003), and LY30(OR, 0.433;95% CI, 0.238-0.788; P=0.012) were independent predictors of RSA. In the Anti-TPO negative group, TAFI (OR, 0.965; 95% CI, 0.935-0.996; P = 0.028), and age (OR, 1.067; 95% CI, 1.026-1.11; P = 0.001) were independent predictors of RSA. It is worth noting that TAFI was shown to be an independent protective factor for RSA in all four groups, except in the Anti-TG negative group.