Acknowledgements
Author contributions . I.C., J.F., A.F., and C.D.D. designed and performed the experiments, analyzed data, and contributed to write the paper. L.P. and P.M. designed the study, supervised the work, analyzed data, and wrote the paper. P.M. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Data availability statement. The data that support the findings of this study are available from the corresponding author upon reasonable request.
Funding/financial support . This study was supported by the EFSD/JDRF/Lilly European Program in Type 1 Diabetes Research, and by grants from Fondazione Italiana Diabete (FID), and the Juvenile Diabetes Research Foundation JDRF (2-SRA-2021-1002-S-B)