Introduction
Acute myeloid leukemia (AML) is typified by the neoplastic clonal expansion of precursor cells and the cessation of differentiation in the bone marrow. (1). According to the American Cancer Society’s projections for 2018, there were an estimated 19,520 new cases of AML and 10,670 deaths resulting from this disease in the United States. Additionally, it is estimated that approximately 0.5% of the US population will develop AML. (2). The age-adjusted mortality rates and incidence are reported as 2.8 and 4.3 per 100,000 individuals, respectively. Additionally, the 5-year survival rate is noted to be 27.4%. (3).
The dysregulation of epigenetics plays a key role in developing various diseases, including cancer. The deconvolution of 200 AML genomes, led by The Cancer Genome Atlas, has demonstrated that a considerable number of these AMLs exhibit mutations in epigenetic regulators. (4). Here, we now report an unusual case of AML with an unreported translocation associated with AML.