Introduction
Acute myeloid leukemia (AML) is typified by the neoplastic clonal
expansion of precursor cells and the cessation of differentiation in the
bone marrow. (1). According to the American Cancer Society’s projections
for 2018, there were an estimated 19,520 new cases of AML and 10,670
deaths resulting from this disease in the United States. Additionally,
it is estimated that approximately 0.5% of the US population will
develop AML. (2). The age-adjusted mortality rates and incidence are
reported as 2.8 and 4.3 per 100,000 individuals, respectively.
Additionally, the 5-year survival rate is noted to be 27.4%. (3).
The dysregulation of epigenetics plays a key role in developing various
diseases, including cancer. The deconvolution of 200 AML genomes, led by
The Cancer Genome Atlas, has demonstrated that a considerable number of
these AMLs exhibit mutations in epigenetic regulators. (4).
Here, we now report an unusual
case of AML with an unreported translocation associated with AML.