3.2 “Very early onset- persistent” eczema shows the highest risk for likelyFA
Participants who suffered from eczema at any point in childhood showed a 3.8 times higher odds of developing likelyFA and a 2.6 times higher risk for indeterminateFA (Supplementary Table 2). The risk of developing likelyFA was significantly higher across all eczema phenotypes when compared to “Never­­­ eczema”. Figure 2 shows that “Very early onset – persistent” eczema displayed a 10.4 times higher odds for developinglikelyFA , followed by “Early onset – persistent” eczema with a 3.9 times higher odds (Figure 2) . Additionally, “Very early onset – persistent”, “Early onset – remitting” or “Early onset – persistent” eczema phenotypes showed a significantly higher risk of indeterminateFA . The results of both “no info on persistence” groups (“Very early onset – no info” N = 23; “Early onset – no info” N = 22) can be found in Supplementary Table 3 , together with comprehensive results for all eczema phenotypes.
3.3 “Very early onset – persistent” eczema shows the highest risk for both asthma and hay fever
Ever eczema was associated with the presence of asthma and hay fever(Supplementary Table 2) . All eczema phenotypes besides the “Late onset” group showed significantly higher risks of having asthma (Supplementary Table 4) . The “Very early onset – persistent” group with a 4.1-times higher odds observed the highest risk for having asthma (Figure 3A) . All eczema phenotypes showed significant associations with hay fever presence(Supplementary Table 5) . The “Very early onset – persistent” group observed the highest risk of having hay fever with 6.6-times higher odds (Figure 3B) .