Conclusion
S5 methylation had better sensitivity and fewer false positives than cytology plus HV16/18 to predict cervical high-grade squamous intraepithelial lesion or worse (≥HSIL+) in a selected cohort (who with abnormal cervical screening results) in an Asian country. Additionally, S5 methylation is potential for providing information to predict progression. Moreover, S5 is a potential classifier in LMICs as affordable methylation tests become available.