Conclusion
S5 methylation had better sensitivity and fewer false positives than
cytology plus HV16/18 to predict cervical high-grade squamous
intraepithelial lesion or worse (≥HSIL+) in a selected cohort (who with
abnormal cervical screening results) in an Asian country. Additionally,
S5 methylation is potential for providing information to predict
progression. Moreover, S5 is a potential classifier in LMICs as
affordable methylation tests become available.