Introduction
Inflammatory bowel disease (IBD) refers to a collection of chronic,
idiopathic inflammatory/autoimmune disorders of the gastrointestinal
tract characterized by relapsing and remitting episodes(1). The two main
types of IBD are Crohn’s disease and ulcerative colitis which lead to a
various type of debilitating symptoms such as abdominal pain, rectal
bleeding, weight loss, and diarrhea. The precise mechanisms underlying
IBD pathogenesis remain unclear but are thought to involve a
dysfunctional interplay between host genetics, the intestinal immune
system, and environmental factors(2). Current evidence suggests IBD
results from an aberrant immune response directed against commensal gut
bacteria in genetically susceptible individuals(3). Multiple genetic
loci have been implicated in IBD risk, including genes involved in
epithelial barrier function, microbial sensing, and immunoregulation.
However, genetics alone cannot explain IBD’s rising incidence,
highlighting the likely contribution of environmental risk factors like
diet, smoking, medications, stress, and the microbiome. Ongoing research
aims to better delineate the complex immunopathogenesis of IBD in order
to identify improved diagnostic markers, prognostic indicators, and
therapeutic targets(4). Moreover, Individuals diagnosed with IBD
frequently encounter an array of difficulties that extend beyond the
gastrointestinal system. One such challenge is the emergence of
mononeuritis multiplex. This association between ulcerative colitis and
mononeuritis multiplex underscores the intricate and multifaceted nature
of these autoimmune disorders. The occurrence of symptoms of one
condition in individuals afflicted by the other warrants careful
examination by medical specialists. This necessitates a thorough
investigation into the underlying reasons and the implementation of
preventive measures. In this case report, we will report a patient who
has encountered ulcerative colitis related to mononeuritis multiplex.