SMV: Snow Mountain Virus
aChi-square test P-value
bInfection was defined as SMV RNA detection in any post-challenge stool sample by specific RT-PCR or RT-qPCR and/or anti-SMV serum IgG conversion by ELISA in any post-challenge serum sample
cIllness was defined as with diarrhea ≥3 loose or liquid stools or ≥300 g of loose or liquid
stools in any continuous 24-h period or one or more vomiting episodes during the inpatient period and
with one additional clinical sign or symptom such as fever, abdominal cramps, nausea, headache, chills, fatigue, or myalgia
Table 4: Comparison of mean illness severity score between subjects infected with
Inoculum 1 and Inoculum 2