3. Conclusion
In conclusion, a novel AIE modified ADSCs-derived nanovesicles encapsulated in click-chemistry hydrogel has been concentrated for deep scald wound treatment and inflammation regulation. Easily accessible adipose stem cells-derived nanovesicles (ANVs) are encapsulated with antibacterial photodynamic aggregation-induced emission photosensitizer (THB) to form THB@ANVs, which has been proved to show outstanding antibacterial and tissue remodeling effect. The THB@ANVs can be delivered by an injectable click-chemistry hydrogel to form a “one-stop” deep scald wound treatment system, which is worth popularizing in wound treatment. We observed the significant role of THB@ANVs hydrogel in regulating scald wound inflammation and promoting cell proliferation and migration, which is expected to achieve the prevention of wound infection sepsis, and will be further studied in our group.