3. Conclusion
In conclusion, a novel AIE modified ADSCs-derived nanovesicles
encapsulated in click-chemistry hydrogel has been concentrated for deep
scald wound treatment and inflammation regulation. Easily accessible
adipose stem cells-derived nanovesicles (ANVs) are encapsulated with
antibacterial photodynamic aggregation-induced emission photosensitizer
(THB) to form THB@ANVs, which has been proved to show outstanding
antibacterial and tissue remodeling effect. The THB@ANVs can be
delivered by an injectable click-chemistry hydrogel to form a
“one-stop” deep scald wound treatment system, which is worth
popularizing in wound treatment. We observed the significant role of
THB@ANVs hydrogel in regulating scald wound inflammation and promoting
cell proliferation and migration, which is expected to achieve the
prevention of wound infection sepsis, and will be further studied in our
group.