5. Conclusion
Collectively, we pointed out the importance of M1 macrophage-centered mutual interaction among immune cells in the fibrotic livers of Mdr2-/- mice and indicated that, through this rationale, PIC Ⅱ is a potential candidate for halting the progression of liver fibrosis.
Conflicts of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.