Acknowledgements
YPR would like to acknowledge funding from EMBL core funding, Wellcome grants (208391/Z/17/Z, 223745/Z/21/Z), and the EU H2020 project EPIC-XS [823839]. JP would like to acknowledge Forschungscampus MODAL (project grant 3FO18501). CD and MB are supported by the National Key Research and Development Program of China (2017YFC0908404, 2017YFC0908405) and the Natural Science Foundation of Chongqing, China (cstc2018jcyjAX0225). The authors acknowledge Dr. Phillip Wilmarth for helpful discussions and assistance with manuscript preparation.