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\begin{document}

\title{BRIEF REPORT Outcomes following intolerance to calcineurin-inhibitor
based graft-versus-host disease prophylaxis in children after allogeneic
hematopoietic cell transplantation}



\author[1]{Ashok Srinivasan}%
\author[1]{Diana Wu}%
\author[1]{Ying Li}%
\author[1]{YU BI}%
\author[1]{Trevor Lannom M}%
\author[1]{Deborah Ward}%
\author[1]{Amr Qudeimat}%
\author[1]{Renee Madden}%
\author[1]{Akshay Sharma}%
\author[1]{Rebecca Epperly}%
\author[1]{Ewelina Mamcarz}%
\author[1]{Aimee Talleur}%
\author[1]{Swati Naik}%
\author[1]{Subodh Selukar}%
\author[1]{Brandon Triplett}%
\affil[1]{St Jude Children's Research Hospital Department of Oncology}%


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  \date{May 27, 2024}


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\begin{abstract}
Calcineurin inhibitors (CNI), cyclosporine and tacrolimus, are commonly
used for pharmacotherapeutic prophylaxis of Graft-vs.-Host disease after
hematopoietic cell transplantation (HCT). Unfortunately, their use is
associated with significant toxicities. While intolerance to CNI is well
defined, there is very little data on how they impact outcomes after HCT
in children. Our retrospective study in a cohort of 82 children, shows a
high intolerance rate of 39\% in this population associated with lower
event free survival and a higher transplant-related mortality.%
\end{abstract}%



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