Key learning point:
The etiology of the Leser-Trélat sign is unknown, it is likely that viral infections like COVID-19 can be associated with eruptive seborrheic keratosis,, although the exact pathogenesis is still not clear.
Introduction
Covid-19 inection is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], a Beta coronavirus. The most common clinical manifestations of COVID-19 are respiratory symptoms. As the pandemic progressed, other aspects were discovered, including cutaneous manifestations of the disease for example erythematous rash, urticaria, vesicle formation, and purpura. (2).
To date, no report has been made of the sudden eruption of seborrheic keratoses following COVID-19 infection.
Sudden onset and rapid increase in size and/or number of seborrheic keratoses is called the Leser-Trélat sign, suggesting a paraneoplastic appearance of internal malignancy,(3). The most frequently associated malignancies are adenocarcinoma of the colon, stomach, lung, or breast, although the Leser-Trélat sign has also been reported in non-malignant conditions, e.g., lepromatous leprosy, (4), erythrodermic pityriasis rubra pilaris, (5), human immunodeficiency virus infection,(6), and human papillomavirus infection.(7,). Leser-Trélat sign can also occur in healthy individuals in the absence of internal malignancy. (8). Herewith, we report a case of eruptive seborrheic keratoses, which presented after recovery from COVID-19 infection in a 50-year-old man.