Only a subset of T cells displays skin affinity. |
Selective skin
homing. |
Skin-related lymphocytes produce immunoregulatory molecules. |
Memory
phenotype with broad capacity for cytokine production. |
Immune recognition of antigen in the skin. |
Preferentially respond to
antigens related to skin. |
HUMAN SKIN DISEASES BESIDES AD |
CLA+
T CELL INVOLVEMENT |
Allergic contact dermatitis |
Response to nickel, cobalt, and chromium
metal allergy.100
|
Alopecia areata |
Th2/Tc2
activation.101
|
Drug-induced allergic reactions |
Response to
drugs.102
|
Guttate psoriasis |
Streptococcus pyogenes induces Th17
response.103
|
Herpes Simplex |
CD8+ T anti-viral
response.104
|
Leprosy |
Antigen-specific response.105
|
Melanoma |
Skin metastasis and response to
therapy.106
|
Papuloerythroderma |
Higher proportion than CLA- of
IL-4, IL-13, IL-22 and IL-31
production.107
|
Plaque Psoriasis |
Response to Streptococcus pyogenes and
relation with clinical status.108
|
Rosacea |
Response to demodex.109
|
Skin dengue infection |
Response to
Dengue.110
|
Vitiligo |
Response to autoantigens.111
|