Author contributions
Conceptualization: LFS-B
Funding acquisition: LFS-B, RMP
Writing - original draft: LSSN, TC, MA, RMP, DLO, DYML, EGY
Disclosures: The authors have declared no conflict of interest.
Word count: 3.226
Abstract: CLA+ memory T cells constitute a small subset of human memory T cells. Circulating skin-homing T cells participate in several aspects of atopic dermatitis, such asStaphylococcus aureus involvement in inflammation, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are related to CLA+ T cell response in patients. The function of CLA+ T cells is closely related to the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
Key words: atopic dermatitis, biomarker, CLA+T cells, skin-homing, translational