Patient’s characteristics
During the study period, 207 pediatric ALL patients in the maintenance phase were treated at our center. Out of these, 46 patients (22%)—with a mean age of 5.8 years and SD of 3.17—experienced 61 episodes of RV infection (7 patients had more than one episode during maintenance therapy). Forty-six percent of the episodes occurred during M1 while 54% during M2. Regarding the type of ALL treatment stratification, 70% were an intermediate risk, while 28% and 2% were in patients with high and standard risk respectively.