The Transcriptome Induced by Bazhen Decoction and its Function in G-quadruplex Resolving and Telomere Maintenance in Progeroid Cells
Chuanbiao Li1, Jie Tian1, Jun Yang1, Qianqian Wang1, Bing Guo1, Liming Huang3, Ying Hu2 *, Ying Luo1 *
  1. Department of Pathophysiology, School of Basic Medicine, Guizhou Medical University, Guizhou, China
  2. Department of Pharmacology, School of Basic Medicine, Guizhou Medical University, Guizhou, China
  3. The Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guizhou, China
*corresponding authors：Ying Luo, luoying@gmc.edu.cn; Ying Hu, gyhuying@qq.com
Mailing address:
School of Basic Medicine, Guizhou Medical University
Huaxi university town, Guiyang, Guizhou, China, Zip code 550025
Data availability: All original data will be available upon request.
Declaration of interest: The authors declare no conflict of interest.
Author Contributions: CL, JT performed the Western blotting and the immunofluorescence staining. JY performed the telomere assay. QW conducted the flow cytometry assay. YH and BG performed the transcriptome analysis. YL and LH designed the study and write the manuscript.
Funding: This work is supported by NSFC grant (32260139), and Guizhou Provincial Natural Science Foundation ([2021]4029, [2022]4017).
Ethics approval: All mouse protocols have been approved by the Animal Care and Use Committee of Guizhou Medical University.