5.1 Clinical manifestations
Serotonin syndrome occurs within hours of taking one or more drugs with
a serotonergic effect. The classic triad of symptoms consists of:
Neuromuscular abnormalities ( clonus, myoclonus, tremor,
hyperreflexia, hypertonicity), autonomic hyperactivity (hyperthermia,
tachycardia, hypertension, diarrhea) and altered mental status
(agitation, confusion, anxiety, coma) 1,4,8. In table
321, these symptoms are tentatively categorized
according to severity.