3.6 DAMPs are highly upregulated during tick feeding
Since RAGE is highly expressed during feeding process of ticks, therefore, we planned to detect the expression of RAGE ligands at the site of tick attachment. By immuno-histochemical study, we detected S100A8- and S100B-specific reactions at the biting sites of ticks on wt mice, whereas expression of these molecules were minimum even at the tertiary infestations in RAGE-/- mice (Figure 3), suggesting the possible roles of RAGE-ligand axis in eliciting tick bite induced inflammation.