3.6 DAMPs are highly upregulated during tick feeding
Since RAGE is highly expressed during feeding process of ticks,
therefore, we planned to detect the expression of RAGE ligands at the
site of tick attachment. By immuno-histochemical study, we detected
S100A8- and S100B-specific reactions at the biting sites of ticks on wt
mice, whereas expression of these molecules were minimum even at the
tertiary infestations in RAGE-/- mice (Figure
3), suggesting the possible roles of RAGE-ligand axis in eliciting tick
bite induced inflammation.