Author information
Author 1,
Bergen Laleli Koc, Department of Obstetrics and Gynecology, Division of
Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital,
Ankara, Turkey. E-mail: bergen.laleli@gmail.com . ORCID ID:
0000-0001-8029-7489
Author 2,
Deniz Oluklu, Department of Obstetrics and Gynecology, Division of
Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital,
Ankara, Turkey. E-mail: denizoluklu9@gmail.com . ORCID ID:
0000-0002-9050-2041
Author 3,
Derya Uyan Hendem, Department of Obstetrics and Gynecology, Division of
Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital,
Ankara, Turkey. E-mail: drderyauyan@gmail.com . ORCID ID:
0000-0003-1866-7295
Author 4,
Dilek Menekse Beser, Department of Obstetrics and Gynecology, Division
of Perinatology, Turkish Ministry of Health Ankara Bilkent City
Hospital, Ankara, Turkey. E-mail: dilekmbeser@gmail.com . ORCID ID:
0000-0002-7022-0610
Author 5,
Berchan Besimoglu, Department of Obstetrics and Gynecology, Division of
Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital,
Ankara, Turkey. E-mail: berhan_besimoglu@yahoo.com . ORCID ID:
0000-0003-0376-2513
Author 6,
Atakan Tanacan, Department of Obstetrics and Gynecology, Division of
Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital,
Ankara, Turkey. E-mail: atakantanacan@yahoo.com . ORCID ID:
0000-0001-8209-8248
Author 7,
Fatma Doga Ocal, Department of Obstetrics and Gynecology, Division of
Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital,
Ankara, Turkey. E-mail: eadoga@yahoo.com . ORCID ID: 0000-0003-4727-7982
Author 8,
Dilek Sahin, Department of Obstetrics and Gynecology, Division of
Perinatology, Ankara Bilkent City Hospital, Turkish Ministry of Health,
University of Health Sciences, Ankara, Turkey. E-mail:
dilekuygur@gmail.com . ORCID ID: 0000-0001-8567-9048
Corresponding author: Bergen Laleli Koc
Mailing address: Department of Obstetrics and Gynecology, Division of
Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital,
Ankara, Turkey.
E-mail: bergen.laleli@gmail.com
Phone number: +905079320818AbstractAim: This study aims to investigate the effects of maternal
asthma on fetal cardiac functions.Methods: The study was planned with 30 pregnant women who
presented to a tertiary health center and were diagnosed with asthma and
60 healthy controls with similar gestational ages. The fetal
echocardiographic assessment was assessed between 33 and 35 weeks of
gestation with pulsed-wave Doppler (PW), M-mode, and tissue Doppler
imaging (TDI). Fetal cardiac functions were compared between maternal
asthma and the control group. Cardiac functions were assessed according
to the duration of maternal asthma diagnosis, as well.Results: Early diastolic function parameters, tricuspid E wave
(p=0.001), and tricuspid E/A ratio (P=0.005) were significantly lower in
the group with maternal asthma. TAPSE and MAPSE values were
statistically lower in the study group than in the control group;
p=0.010 and p=0.012, respectively. Parameters assessed with TDI (E’, A’,
S’, E/E’, and MPI’ of tricuspid valves) and global cardiac function
parameters assessed with pulsed-wave Doppler like myocardial performance
index (MPI) and left cardiac output (LCO) were similar between groups
(p> 0.05). Although, MPI did not change between groups, and
the isovolumetric relaxation time (IVRT) value was prolonged in maternal
asthma cases (p=0.025).Conclusion: We found that maternal asthma disease causes
alteration in fetal diastolic and early systolic cardiac functions, but
the global fetal cardiac function does not change. Diastolic heart
function values also varied with the duration of maternal asthma.
Prospective studies are needed to compare fetal cardiac functions with
additional patient groups according to disease severity and type of
medical treatment.Keywords: fetal echocardiography, asthma, pregnancy, fetal
cardiac function.