Discussion:
Males between the ages of 15 and 35 most frequently develop testicular tumors, which have an improving rate of complete recovery. Seminoma usually spreads metastatically along the lymphatic drainage routes to the retroperitoneal lymph nodes; however, involvement of the kidney, adrenal gland, psoas muscle, stomach, seminal vesicle, bladder, prostate, and pericardium is rarely present (<1%).10
For testis tumors, metastases during the first two years are considered as early, whereas those after five years are categorized as late. The majority of metastases occur within the first two years.11 We present a case of very late seminoma metastases that occurred after 25 years.
In a research conducted by the husband and colleagues on 650 patients with testicular malignancies who underwent CT, only 6 patients showed kidney metastases, of which 2 were seminomas. This study demonstrates the uncommon frequency of renal seminoma metastases.10
Castelán et al describe a case of a 24-year-old man who underwent a left radical orchiectomy as a result of classic seminoma, left renal metastases from seminoma were also discovered in this instance.8 Despite this, the renal metastasis in our patient occurred 25 years after the initial seminoma presentation.
Malignant tumors are the most frequent cause of neck masses in adults, and neck involvement may frequently be the first or only clinical symptom 12 and Neck metastases from uterine, ovarian, prostate, and testicular malignancies have been described seldom. Supraclavicular metastases can develop in men as their prostate and testicular cancers progress. 13
Considering that 4.5-15% of seminoma patients may experience neck metastases during the course of the disease, the neoplastic diffusion to the cervical lymph node is not an unusual presentation of the disease.14, 15
A 59-year-old man who presented with a left indolent neck swelling that had developed gradually over 6 months is the focus of a case study by Corazzi and colleagues. The clinical history of the patient revealed a left testicular seminoma that had undergone surgery and adjuvant treatment 20 years ago. 12
To the best of our knowledge, no other examples of seminoma metastases to the kidney, cervical, and base of the skull occurring simultaneously after a 25-year interval have been documented in the literature.