9.3 BAs-based therapy
Researchers have synthesized LCA 3-sulfate (LCA-3-S) that binds to RORγt
and selectively suppresses Th17 cell
differentiation127. UDCA has been used clinically for
many years and has a good curative effect on PSC128.It
also degrade TGF-β and inhibits the differentiation and activation of
Treg cells129, and UDCA enhances the anti-tumor
efficacy of anti-pd-1. Researchers have established a set of steps that
contain the necessary enzymes and engineer them into Clostridium
sporogenes, successfully producing DCA and LCA130.
This also provides us with hope to take advantage of gut flora. Natural
extraction or artificial synthesis of BAs and reasonable combinations of
several kinds to achieve smooth regulation of Th17 and Treg cells is a
promising method for the treatment of IBD and other diseases. However,
drug therapy also needs to consider the condition of the patient’s gut
so that it can be tailored to each individual.