Case report
A 61-year-old woman, with no medical history, was diagnosed with viral
hepatitis C and started treatment with the combination ledipasvir
sofosbuvir in June 2020, 400 mg per day.
Five weeks after starting the treatment, she developed a slightly itchy
erythematous rash on lower members. The patient initially suspected the
treatment and she stopped it.
Physical examination revealed purpuric lesions with confluent
erythematous macules at the lower third of the thighs reaching the
knees. Lesions were symmetrical. Skin biopsy was performed. Histological
finding revealed a diffuse neutrophile infiltration of vessel walls
confirming leucocytoclasic vasculitis.
Lesions disappeared completely three days after drug withdrawal without
any symptomatic treatment.