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\begin{document}

\title{Emergence of a young case infected with avian influenza A (H5N6) in
Anhui Province, East China during the COVID-19 pandemic}



\author[1]{Hai-Feng Pan}%
\author[2]{Jun-Ling Yu}%
\author[2]{Sai Hou}%
\author[1]{Ya-Ting Feng}%
\author[3]{Ge Bu}%
\author[2]{Qing-Qing Chen}%
\author[3]{Zhao-Qian Meng}%
\author[3]{Zhen-Tao Ding}%
\author[3]{Liang-Zi Guo}%
\author[2]{Xue Zhou}%
\author[2]{Meng Wang}%
\author[1]{Xin-Er Huang}%
\author[2]{Wei-Wei Li}%
\author[2]{Lan He}%
\author[2]{Lei Gong}%
\author[2]{Yong  Sun}%
\author[4]{Zhiwei Xu}%
\author[2]{Jun He}%
\author[2]{Jia-Bing Wu}%
\affil[1]{Anhui Medical University}%
\affil[2]{Anhui Provincial Center for Disease Control and Prevention}%
\affil[3]{Fuyang City Center for Disease Control and Prevention Fuyang China}%
\affil[4]{The University of Queensland School of Public Health}%


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  \date{May 26, 2024}


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\begin{abstract}
In the context of the COVID-19 pandemic, we investigated the
epidemiological and clinical characteristics in a young patient infected
by avian influenza A (H5N6) virus in Anhui Province, East China, and
analyzed genomic features of the pathogen. Through the cross-sectional
investigation of external environment monitoring (December 29-December
31, 2020), 1 909 samples were collected from Fuyang City. It was found
that the positive rate of H5N6 in Tianma poultry market was higher than
other areas obviously, where the case appeared. The virus was the clade
2.3.4.4, which was most likely formed by genetic reassortment between
H5N6 and H9N2 viruses. This study found that the evolution rates of HA
gene and NA gene of the virus were higher than those of common seasonal
influenza viruses. The virus was still highly pathogenic to poultry, and
had a preference for avian receptor binding.%
\end{abstract}%



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