|
|
|
Mutation Rate in European descendant (%) |
Mutation Rate in
African descendant (%) |
Reference |
BRCA 1
|
x
|
PARPi
|
0.5%
0.77%
0.87%
|
2.0%
0.0%
0.0%
|
Ledet et al.64
Na et al.70
Pritchard et al.65
|
BRCA 2
|
x
|
PARPi
|
5.0%
3.07%
4.77%
5.10%
|
4.0%
0.0%
0.0%
0.90%
|
Ledet et al.64
Na et al.70
Pritchard et al.65
Plym et al.71
|
ATM
|
x
|
PARPi
|
1.0%
1.53%
1.01%
|
0.0%
3.33%
0.14%
|
Ledet et al.64
Na et al.70
Pritchard et al.65
|
PALB2
|
x
|
|
0.50%
0.43%
|
0.50%
0.0%
|
Ledet et al.64
Pritchard et al.65
|
CHECK2
|
x
|
PARPi
|
2%
1.01%
|
0.0%
0.0%
|
Ledet et al.64
Pritchard et al.65
|
MSH2
|
x
|
Checkpoint Inhibitor
|
0.20%
0.14%
0.70%
|
0.0%
0.0%
1.80%
|
Ledet et al.64
Pritchard et al.65
Plym et al.71
|
MSH6
|
x
|
Checkpoint Inhibitor
|
0.50%
0.14%
0.30%
|
0.50%
0.0%
0.00%
|
Ledet et al.64
Pritchard et al.65
Plym et al.71
|
PMS2
|
x
|
Checkpoint Inhibitor
|
0.30%
0.70%
|
0.50%
0.00%
|
Ledet et al.64
Plym et al.71
|
FANCA |
x |
PARPi |
0.30% |
0.00% |
Plym et
al.71
|
NBN
|
x
|
PARPi
|
1%
0.14%
0.00%
|
0.0%
0.0%
0.90%
|
Ledet et al.64
Pritchard et al.65
Plym et al.71
|